2021-11-01 - Cancer Synoptic Reporting Project Group Meeting

• Confirm date of 2021-10-31 availability

1. Discuss representation of "intactness" and specimen quality (colon, ovary, thyroid)
   
   
2. Confirm Business Meeting Conclusion

Approach agreed upon.  Create new concept |Anatomic integrity (property)|.  When used with |Inheres in| = some (specimen), then the discussion is about the anatomic integrity of the specimen which is appropriate for CSRWG observations.

When used with |Inheres in| = some (body structure), the discussion is about the anatomic integrity of the body structure as is the case discussed pertaining to in vivo observations.

1. What phase(s)

number cell in Cell division phase phase/total count of cells in a normalized area

1. Mitotic rate = count/area = > #mitoses/area

2. Ki-67=> proliferation fraction...# cells expressing ?/total count in a specific area  mitotic cell state/resting state

Inclusion of primary tumor site in observable as |Inherent location| in metastatic spread observables

Review sample concept

Review model for colon and appendix

Discuss with # of Tumor Deposits

Model review and discussion

ER, PR, Her2, Ki-67, PD-L1, MLH1, PMS2, MSH2, MSH6,ATRX expression, Beta-catenin expression, reticulin

How are these broken out/logically organized?  Nuclear proteins? Cytoplasmic: Receptors?