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In advance of our next call in December I am posting 2 files created by the allergy update project for review by our group. The first file contains a list of allergen/pseudoallergen classes. We wish to solicit input from this group as to whether these need to be retained in the revisions to the substance hierarchy. Note that the use of allergen classes (as opposed to just substances) has been used only infrequently for the modeling of allergies. The second file lists all of the descendants of allergic disposition and some questionable groupers which we need to determine clinical relevance for in order to guide the modeling of the causative agents in the substance hierachy

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