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In the Netherlands we have an intensional reference set for allergens in our extension (excluding drug allergens). We find that there are a (lots of) concepts that are not descendant of allergen class, for example mustard seed and shellfish. And lots of concept that are allergens are not in Snomed yet. I wasnt able to join the last meetings unfortunately but I read that you are planning to create reference sets, will that also include allergen substances reference set? And is there a plan to review the substance hierarchy as a whole in the upcoming future? I will be able to join at the business meetings in Londen!