B.2 Invalid Refinements

Expression Constraint	INVALID Expression¹ ²
	Precoordinated	Postcoordinated
< 19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|	19829001 \|Disorder of lung\|	19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 44132006 \|Abscess\|
	73452002 \|Abscess of lung\|
		19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 40829002 \|Acute edema\|
	233711002 \|Oxygen-induced pulmonary edema\|
< 19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = << 79654002 \|Edema\|	19829001 \|Disorder of lung\|	6141006 \|Retinal edema\| : 116676008 \|Associated morphology\| = 103619005 \|Inflammatory edema\|
	73452002 \|Abscess of lung\|
		19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 44132006 \|Abscess\|
	6141006 \|Retinal edema\|
< 404684003 \|Clinical finding\| : 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\|	404684003 \|Clinical finding\|	448643005 \|Abnormality of pulmonary valve\| : 116676008 \|Associated morphology\| = 44132006 \|Abscess\|
	448643005 \|Abnormality of pulmonary valve\|
		404684003 \|Clinical finding\| : 363698007 \|Finding site\| = 61853006 \|Spinal canal structure\| , 116676008 \|Associated morphology\| = 415582006 \|Stenosis\|
	431238002 \|Abscess of pulmonary valve\|
* : 246075003 \|Causative agent\| = 387517004 \|Paracetamol\|	46093004 \|Paracetamol measurement\|	404684003 \|Clinical finding\| : 246075003 \|Causative agent\| = 372687004 \|Amoxicillin\|
< 404684003 \|Clinical finding\| : { 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\| }, { 363698007 \|Finding site\| = << 53085002 \|Right ventricular structure\| , 116676008 \|Associated morphology\| = << 56246009 \|Hypertrophy\| }	404684003 \|Clinical finding\|	< 404684003 \|Clinical finding\| : { 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 56246009 \|Hypertrophy\| }, { 363698007 \|Finding site\| = << 53085002 \|Right ventricular structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\| }
	56786000 \|Pulmonary valve stenosis\|
< 404684003 \|Clinical finding\| : 47429007 \|Associated with\| = ( < 404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = << 55641003 \|Infarct\| )	3238004 \|Pericarditis\|	64572001 \|Disease\| : 47429007 \|Associated with\| = ( 404684003 \|Clinical finding\| : 363698007 \|Finding site\| = 277712000 \|Cardiac internal structure\| )
< 404684003 \|Clinical finding\| : << 47429007 \|Associated with\| = << 267038008 \|Edema\|	404684003 \|Clinical finding\|	95356008 \|Mucosal ulcer\| : 42752001 \|Due to\| = 59901004 \|Cheek biting\|
< 111115 111115 \|Amoxicillin tablet\| : { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| >= #500, 111115 500111115 \|Strength unit\| = 258684004 \|mg\| }	111115 111115 \|Amoxicillin tablet\|	111115 111115 \|Amoxicillin tablet\| : 111115 111115 \|Has dose form\| = 421026006 \|Oral tablet\| , { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| = #450, 111115 450111115 \|Strength unit\| = 258684004 \|mg\| }
	111115 111115 \|Amoxicillin trihydrate 450 mg tablet\|
< 111115 111115 \|Amoxicillin tablet\| : { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| >= #500, 111115 500111115 \|Strength magnitude equal to\| <= #800, 111115 800111115 \|Strength unit\| = 258684004 \|mg\| }	111115 111115 \|Amoxicillin tablet\|	111115 111115 \|Amoxicillin tablet\| : { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| = #820, 111115 820111115 \|Strength unit\| = 258684004 \|mg\| }
	111115 111115 \|Amoxicillin trihydrate 820 mg tablet\|
< 373873005 \|Pharmaceutical / biologic product\| : 111115 111115 \|Trade name\| = "PANADOL"	373873005 \|Pharmaceutical / biologic product\|	373873005 \|Pharmaceutical / biologic product\| : { 127489000 \|Has active ingredient\| = 412031009 \|Paracetamol or derivative\| }
	111115 111115 \|Paracetamol tablet\|
< 91723000 \|Anatomical structure\| : R 363698007 \|Finding site\| = < 125605004 \|Fracture of bone\|	34080009 \|Malleus structure\|	34080009 \|Malleus structure\| : 272741003 \|Laterality\| = 7771000 \|Left\|
	10200004 \|Liver structure\|	10200004 \|Liver structure\| : 272741003 \|Laterality\| = 24028007 \|Right\|
< 125605004 \|Fracture of bone\| . 363698007 \|Finding site\|	34080009 \|Malleus structure\|	34080009 \|Malleus structure\| : 272741003 \|Laterality\| = 7771000 \|Left\|
	10200004 \|Liver structure\|	10200004 \|Liver structure\| : 272741003 \|Laterality\| = 24028007 \|Right\|
< 105590001 \|Substance\| : R 127489000 \|Has active ingredient\| = 111115 111115 \|TRIPHASIL tablet\|	105590001 \|Substance\|	373873005 \|Pharmaceutical / biologic product\| : 127489000 \|Has active ingredient\| = 126109000 \|Levonorgestrel\|
	387517004 \|Paracetamol\|
111115 111115 \|TRIPHASIL tablet\| . 127489000 \|Has active ingredient\|	105590001 \|Substance\|	373873005 \|Pharmaceutical / biologic product\| : 127489000 \|Has active ingredient\| = 126109000 \|Levonorgestrel\|
	387517004 \|Paracetamol\|
< 404684003 \|Clinical finding\| : * = 79654002 \|Edema\|	263225007 \|Hip fracture\|	404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = 72704001 \|Fracture\|
	385933006 \|Edema control education\|
< 404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = *	195967001 \|Asthma\|	404684003 \|Clinical finding\| : 363698007 \|Finding site\| = 80891009 \|Heart structure\|
	73211009 \|Diabetes mellitus\|	404684003 \|Clinical finding\| : 246075003 \|Causative agent\| = 372687004 \|Amoxicillin\|

Footnotes
Ref	Notes
1	Please note that some of these examples are based on a hypothetical drug concept model.
2	Concepts for which an identifier has not yet been assigned have been shown with an identifier of ‘111115’.

Expression Constraint	INVALID Expression¹ ²
	Precoordinated	Postcoordinated
< 19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|	19829001 \|Disorder of lung\|	19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 44132006 \|Abscess\|
	73452002 \|Abscess of lung\|
		19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 40829002 \|Acute edema\|
	233711002 \|Oxygen-induced pulmonary edema\|
< 19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = << 79654002 \|Edema\|	19829001 \|Disorder of lung\|	6141006 \|Retinal edema\| : 116676008 \|Associated morphology\| = 103619005 \|Inflammatory edema\|
	73452002 \|Abscess of lung\|
		19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 44132006 \|Abscess\|
	6141006 \|Retinal edema\|
< 404684003 \|Clinical finding\| : 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\|	404684003 \|Clinical finding\|	448643005 \|Abnormality of pulmonary valve\| : 116676008 \|Associated morphology\| = 44132006 \|Abscess\|
	448643005 \|Abnormality of pulmonary valve\|
		404684003 \|Clinical finding\| : 363698007 \|Finding site\| = 61853006 \|Spinal canal structure\| , 116676008 \|Associated morphology\| = 415582006 \|Stenosis\|
	431238002 \|Abscess of pulmonary valve\|
* : 246075003 \|Causative agent\| = 387517004 \|Paracetamol\|	46093004 \|Paracetamol measurement\|	404684003 \|Clinical finding\| : 246075003 \|Causative agent\| = 372687004 \|Amoxicillin\|
< 404684003 \|Clinical finding\| : { 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\| }, { 363698007 \|Finding site\| = << 53085002 \|Right ventricular structure\| , 116676008 \|Associated morphology\| = << 56246009 \|Hypertrophy\| }	404684003 \|Clinical finding\|	< 404684003 \|Clinical finding\| : { 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 56246009 \|Hypertrophy\| }, { 363698007 \|Finding site\| = << 53085002 \|Right ventricular structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\| }
	56786000 \|Pulmonary valve stenosis\|
< 404684003 \|Clinical finding\| : 47429007 \|Associated with\| = ( < 404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = << 55641003 \|Infarct\| )	3238004 \|Pericarditis\|	64572001 \|Disease\| : 47429007 \|Associated with\| = ( 404684003 \|Clinical finding\| : 363698007 \|Finding site\| = 277712000 \|Cardiac internal structure\| )
< 404684003 \|Clinical finding\| : << 47429007 \|Associated with\| = << 267038008 \|Edema\|	404684003 \|Clinical finding\|	95356008 \|Mucosal ulcer\| : 42752001 \|Due to\| = 59901004 \|Cheek biting\|
< 111115 111115 \|Amoxicillin tablet\| : { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| >= #500, 111115 500111115 \|Strength unit\| = 258684004 \|mg\| }	111115 111115 \|Amoxicillin tablet\|	111115 111115 \|Amoxicillin tablet\| : 111115 111115 \|Has dose form\| = 421026006 \|Oral tablet\| , { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| = #450, 111115 450111115 \|Strength unit\| = 258684004 \|mg\| }
	111115 111115 \|Amoxicillin trihydrate 450 mg tablet\|
< 111115 111115 \|Amoxicillin tablet\| : { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| >= #500, 111115 500111115 \|Strength magnitude equal to\| <= #800, 111115 800111115 \|Strength unit\| = 258684004 \|mg\| }	111115 111115 \|Amoxicillin tablet\|	111115 111115 \|Amoxicillin tablet\| : { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| = #820, 111115 820111115 \|Strength unit\| = 258684004 \|mg\| }
	111115 111115 \|Amoxicillin trihydrate 820 mg tablet\|
< 373873005 \|Pharmaceutical / biologic product\| : 111115 111115 \|Trade name\| = "PANADOL"	373873005 \|Pharmaceutical / biologic product\|	373873005 \|Pharmaceutical / biologic product\| : { 127489000 \|Has active ingredient\| = 412031009 \|Paracetamol or derivative\| }
	111115 111115 \|Paracetamol tablet\|
< 91723000 \|Anatomical structure\| : R 363698007 \|Finding site\| = < 125605004 \|Fracture of bone\|	34080009 \|Malleus structure\|	34080009 \|Malleus structure\| : 272741003 \|Laterality\| = 7771000 \|Left\|
	10200004 \|Liver structure\|	10200004 \|Liver structure\| : 272741003 \|Laterality\| = 24028007 \|Right\|
< 125605004 \|Fracture of bone\| . 363698007 \|Finding site\|	34080009 \|Malleus structure\|	34080009 \|Malleus structure\| : 272741003 \|Laterality\| = 7771000 \|Left\|
	10200004 \|Liver structure\|	10200004 \|Liver structure\| : 272741003 \|Laterality\| = 24028007 \|Right\|
< 105590001 \|Substance\| : R 127489000 \|Has active ingredient\| = 111115 111115 \|TRIPHASIL tablet\|	105590001 \|Substance\|	373873005 \|Pharmaceutical / biologic product\| : 127489000 \|Has active ingredient\| = 126109000 \|Levonorgestrel\|
	387517004 \|Paracetamol\|
111115 111115 \|TRIPHASIL tablet\| . 127489000 \|Has active ingredient\|	105590001 \|Substance\|	373873005 \|Pharmaceutical / biologic product\| : 127489000 \|Has active ingredient\| = 126109000 \|Levonorgestrel\|
	387517004 \|Paracetamol\|
< 404684003 \|Clinical finding\| : * = 79654002 \|Edema\|	263225007 \|Hip fracture\|	404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = 72704001 \|Fracture\|
	385933006 \|Edema control education\|
< 404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = *	195967001 \|Asthma\|	404684003 \|Clinical finding\| : 363698007 \|Finding site\| = 80891009 \|Heart structure\|
	73211009 \|Diabetes mellitus\|	404684003 \|Clinical finding\| : 246075003 \|Causative agent\| = 372687004 \|Amoxicillin\|

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B.2 Invalid Refinements