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Mapping of LOINC Part components used in susceptibility LOINC terms, specifically the ones that contain more than one antibiotics:
18865-6 | Ampicillin+Sulbactam | Susc | Pt | Isolate | OrdQn | |
20374-5 | Ampicillin+Sulbactam | Susc | Pt | Isolate | OrdQn | Method for Slow-growing mycobacteria |
43251 | Ampicillin+Sulbactam | Susc | Pt | Isolate | Qn | MLC |
11749 | Ampicillin+Sulbactam | Susc | Pt | Isolate | OrdQn | MIC |
12055 | Ampicillin+Sulbactam | Susc | Pt | Isolate | OrdQn | Agar diffusion |
1855616 | Ampicillin+Sulbactam | Susc | Pt | Isolate | OrdQn | Gradient strip |
And the ones that contain strength:
48177-0 | Streptomycin 1.0 ug/mL | Susc | Pt | Isolate | OrdQn | Method for Slow-growing mycobacteria |
25206-4 | Streptomycin 10.0 ug/mL | Susc | Pt | Isolate | OrdQn | Method for Slow-growing mycobacteria |
25205-6 | Streptomycin 2.0 ug/mL | Susc | Pt | Isolate | OrdQn | Method for Slow-growing mycobacteria |
46719-1 | Streptomycin 4.0 ug/mL | Susc | Pt | Isolate | OrdQn | Method for Slow-growing mycobacteria |
25185-0 | Streptomycin 6.0 ug/mL | Susc | Pt | Isolate | OrdQn | Method for Slow-growing mycobacteria |
This issue needs to be considered in association with CTP Project - Elaboration document on Susceptibility:
The modelling design (using the deposition observable / flattened format) is as follows:
‘‘Observable entity’ and
‘property type’ some ‘Susceptibility’ and
‘towards’ some <LOINC.component> and
‘technique’ some <LOINC.method> and
‘scale’ some <LOINC.scale>
‘time aspect’ some ‘Single point in time”
‘inheres in’ some ‘Microorganism’ and
'Direct site = 119303007 | Microbial isolate specimen (specimen) |'
In mapping ‘towards’ some <LOINC.component>:
1) We have mapped the LOINC parts containing one antibiotic to the equivalent substance
LP28719-0 1 Gatifloxacin (Mapped to: 116349004 Gatifloxacin (substance))
LP33354-9 1 Daptomycin (Mapped to: 406439009 Daptomycin (substance))
2) For the ones containing multiple substances, see the latest associated guideline for compound substances:
Combined substances added to the Substance hierarchy must meet the following criteria:
- The physiologic or biologic action of the combination must be enhanced or synergistic
- Combinations that do not have an enhanced or synergistic effect (e.g. combinations created for convenience) are out of scope.
Examples of combined substances that are in scope include:Ampicillin + sulbactamPiperacillin + tazobactam
Examples:
LP15937-3 1 Ampicillin+Sulbactam (Mapped to: 703744001 | Ampicillin and sulbactam (substance) |. A product concept also exist: 398786001 Product containing ampicillin and sulbactam (medicinal product))
LP29104-4 1 Quinupristin+Dalfopristin (No susbtance concept created yet. Product concept: 324352008 Product containing dalfopristin and quinupristin (medicinal product))
3) LOINC terms with an antibiotic component with strength specified:
LP229026-2 1 COMPONENT Moxifloxacin 0.5 ug/mL
LP229027-0 1 COMPONENT Moxifloxacin 1.0 ug/mL
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