Autoimmune disorder - in process

Hello Yongsheng Gao Please review this template. Thank you. Nicki

Nicola Ingram  I updated some ranges for the model.  There are over 80 concepts are modelled by the due to relationships. It might be better to restrict this template to the simple pattern by removing the due to attribute. Otherwise, you will need to address all association patterns. 

Nicola Ingram , I have updated the cardinality for |finding site| and range for |occurrence|. The misalignment report does not include complex associations. I think this template is ready for implementation unless you need to make further changes. Cheers,  Yong

Hi Yongsheng GaoI added a new path process = hypersensitivity process to the template - does it look OK

Hi Yongsheng Gao moved back to In review as I had made some changes can you check the Template and the Template language for me - thanks

It is causing a problem for the group remodel process to have both a grouped and an ungrouped pathological process - we've not seen that before.   I could add some code to be more strict with the alignment of ungrouped, optional attributes.   

The template does at least explain why I've been seeing odd results in QI-297.   The remodel is attempting to fill the template as much as it can, but in the this case, it should give up sooner since the ungrouped attribute is optional.

Hi Nicola Ingram  the additional Causative agent = <<  30621004 |Autoantibody (substance)| and Pathological process = <<  472963003 |Hypersensitivity process (qualifier value)| seems to be used for representing type II hypersensitivity conditions, such as Myasthenia gravis, Graves disease. I think these two attribute/value pairs need to be grouped together. It might be useful to create a new template for type II hypersensitivity conditions. Then, autoimmune disorder would be a generic template without these two attribute/value pairs. Please check with Bruce Goldberg  for his expertise in immunology. 

Thanks Bruce Goldberg I think we should produce a separate template for hypersensitivity conditions that are autoimmune. I am wondering if the types of hypersensitivity can help to identify hypersensitivity conditions that are autoimmune. The guidance would be helpful for authors to choose the right template for modeling. Then, this template would only represent specific autoimmune conditions (exclude hypersensitivities). The other issue with the current template is that it won't facilitate identifying the misaligned concepts since these additional attributes are optional. 

Hi Yongsheng Gao. Organism should not be a value of causative agent for autoimmune diseases as the organism itself does not cause the autoimmunity but rather the immune response to the organism. In those cases due to or due to and after relationships to the infection caused by the organism can be used. An additional pathological process can be included in role group 1 in order to define those autoimmune disorders that represent hypersensitivity once these more specific hypersensitivity processes are created. I originally had this in the template.

Cheers,

Bruce

Hi Yongsheng Gao. Yes, this will need 2 pathological processes if we want to describe specific hypersensitivity processes such as delayed type hypersensitivity as these are not necessarily autoimmune. Same thing for Allergic contact dermatitis. If we want to add delayed type hypersensitivity as a pathological process we would need it in a second role group from allergic contact hypersensitivity because delayed type hypersensitivity is involved in diseases not considered to be allergic. I will modify the template for now but I will need to do more testing. Modeling autoimmune disorders will be difficult as the mechanisms will need to be researched and in some cases more than one mechanism may be involved and in many the mechanisms may be unknown.