Value sets (attribute, cardinality, binding strength)
All SNOMED CT value set bindings in the base resource are example bindings, but could be made required or extensible in a SNOMED CT-focused profile.
The discussion below considers pre-coordinated content (as of 2017-07-31 international release of SNOMED CT).
AllergyIntolerance Substance/Product, Condition and Negation Codes (AllergyIntolerance.code, 0..1, Example)
The value set contains substances, products, some conditions and also some negation (situation) concepts. Making different choices within the value set may lead to lack of interoperability, e.g. 293584003 |Allergy to paracetamol (disorder)| is not equivalent to 387517004 |Paracetamol (substance)| or to 322237000 |Paracetamol 500mg soluble tablet (product)| but "transforms" can be made in some cases through the concept model, e.g. code = 293584003 |Allergy to paracetamol (disorder)| → code = 387517004 |Paracetamol (substance)| and vice versa, but code = 322237000 |Paracetamol 500mg soluble tablet (product)| does not necessarily imply code = 387517004 |Paracetamol (substance)| or, more clearly, code = 358501001 |Paracetamol+caffeine 500mg/65mg soluble tablet (product)| does not imply code = 387517004 |Paracetamol (substance)| (nor code = 293584003 |Allergy to paracetamol (disorder)| ) while the opposite holds.
Ruled-out specific allergies or intolerances can be represented either using verificationStatus = refuted or using code = <negation code> from this value set, or possibly an extended value set. "No known (X) allergies" may also be represented as an empty list and a specific emptyReason.
Other overlaps include overlap between code and category, type and and between reaction.manifestation and reaction.severity.
Substance Code (AllergyIntolerance.reaction.substance, 0..1, Example)
The value set contains substances and products, thus see discussion above.
SNOMED CT Clinical Findings (AllergyIntolerance.reaction.manifestation, 1..*, Example)
The value set contains all clinical findings (<< 404684003 |Clinical finding (finding)|) and could possibly be more constrained like <<282100009 |Adverse reaction caused by substance (disorder)| (although this set probably does have (significant) gaps and overlaps (e.g. 735449006 |Hypersensitivity reaction caused by food (disorder)|)).
SNOMED CT Route Codes (AllergyIntolerance.reaction.exposureRoute, 0..1, Example)
The value set contains routes of administration primarily developed for drug use (<<284009009 |Route of administration value (qualifier value)|) and should be reviewed for gaps (e.g. what is the route(s) for a cat dander reaction, noting that reaction.exposureRoute is not mandatory)
Mapping (atribute, cardinality, binding strength)
AllergyIntoleranceClinicalStatus (AllergyIntolerance.clinicalStatus, 0..1, Required)
active | inactive | resolved
AllergyIntoleranceVerificationStatus (AllergyIntolerance.verificationStatus, 1..1, Required)
unconfirmed | confirmed | refuted | entered-in-error
AllergyIntoleranceType (AllergyIntolerance.type, 0..1, Required)
allergy | intolerance
AllergyIntoleranceCategory (AllergyIntolerance.category, 0..*, Required)
food | medication | environment | biologic
AllergyIntoleranceCriticality (AllergyIntolerance.criticality, 0..1, Required)
low | high | unable-to-assess
AllergyIntoleranceSeverity (AllergyIntolerance.reaction.severity, 0..1, Required)
mild | moderate | severe
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