In the disorder hierarchy, the word 'disorder' in singular should be used. When the concept is a general grouper of disorders of a body system, body site, or other broad general category, the word 'disorder' should be used in preference to 'disease' for the FSN. This rule in favor of 'disorder' over 'disease' applies only to broad groupers, and is not applied at 'leaf' level. Plurals such as 'disorders' or 'diseases' may only be used in synonym terms for grouper concepts.
|Strings should avoid the article 'the' in the string.|
|At a general level, use:||Instead of:|
|Disorder of nose||Diseases of the nose|
|Disorder of reproductive system||Disease of the reproductive system|
|Disorder of lower respiratory system||Disease of the lower respiratory system|
FSN: Adverse reaction caused by abacavir (disorder)
PT: Adverse reaction caused by abacavir
2. Where BAN (British Approved Name) and/or USAN (United States Adopted Name) differs from the INN, then synonyms should be added using the following pattern (Z = BAN or USAN)
FSN: Adverse reaction caused by paracetamol (disorder)
PT: Adverse reaction caused by paracetamol
Syn: Adverse reaction caused by acetaminophen
FSN: Adverse reaction caused by Artemisia vulgaris pollen (disorder)
PT: Adverse reaction caused by mugwort
Syn: Adverse reaction caused by Artemisia vulgaris pollen
FSN: Adverse reaction caused by sulfamethoxazole and trimethoprim (disorder)
PT: Adverse reaction caused by sulfamethoxazole and trimethoprim
FSN: Adverse reaction caused by ibuprofen and paracetamol (disorder)
PT: Adverse reaction caused by ibuprofen and paracetamol
Syn: Adverse reaction caused by acetaminophen and ibuprofen
The following illustrates proximal primitive modeling for multiple ingredient concepts fitting the pattern described in this document:
Note: It is agreed that this modeling approach for multiple ingredient concepts is an interim solution as it is incorrectly it asserts an adverse reaction to each, rather than to one, of the agents. The use of concepts from the Product hierarchy is being considered as a final solution but further work is required to determine if this would be a viable solution.
When reviewing the classification for “Adverse reaction to X” concepts, it is important to confirm that the concept does not have inferred Causative agent attributes as no use case where this would be appropriate has been identified. In the event this occurs, further changes to will be required to correct the problem.
Inferring Causative agent attributes results in incorrect content (e.g. infers a causative agent that is more general or different than what is stated in the concept modeling) and makes the concept unsuitable for use in clinical decision support implementations.