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Allergy concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

• 294418003 |Allergy to phenol (finding)|
  

Expected classification (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling in the Substance hierarchy.

Example:

293908005 |Allergy to chloral hydrate (finding)|

Chloral hydrate is a sedative and may not be well-represented by "Chloral derivative".

Expected classification (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy. Concepts modeled using a modification should have the concept modeled using the base as an inferred parent if such a concept exists.
  • 782530003 |Allergy to chloral derivative (finding)| will be modeled with Causative agent = 418037002 |Chloral derivative (substance)| and will have the following inferred descendants:
    
    • 293908005 |Allergy to chloral hydrate (finding)|
      

Example:

• 294275005 |Allergy to opioid receptor antagonist (finding)|
  

Expected classification results (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling in the Substance hierarchy for concepts modeled with an attribute value from the Substance hierarchy.

Example:

• 782607004 |Allergy to phenothiazine derivative (finding)|

Expected classification (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.

Role groupers in the Substance hierarchy will be inactivated in a future release and should not be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)

No use case has been identified for use of this concept type for modeling in this subhierarchy. Structure groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)

Example:

417930000 |Allergy to adhesive agent (finding)|Expected classification results: NEEDS INTERNAL AGREEMENT

• Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.

Example:

• 294522005 |Allergy to ampicillin and cloxacillin (finding)|

Expected classification results: NEEDS INTERNAL AGREEMENT

• 294650000 |Allergy to vaccine product containing Mumps orthorubulavirus antigen (finding)|

https://confluence.ihtsdotools.org/display/IAP/Allergy+to+X+vaccine