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StatusReady for implementation
Version

2.7

Version in PROD2.0


Descriptions:

Termdescription typeLanguage/acceptabilityLangaugeLanguage/acceptabilityCase significanceSignificance

Allergy to [substance or product] (finding)

FSNus:Pgb:Pci

Allergy to [substance or product]

SYNus:Pgb:Pci
[substance or product] allergySYNus:Agb:Aci


Concept model:

1*N/A[agent]<< <<
Attribute Group CardinalityAttribute CardinalityAttribute in Group CardinalityAttributeValueRole group cardinality

1..10..0


Scg expression
116680003|Is a (attribute)|



Scg expression
420134006|Propensity to adverse reactions (finding)|


1..1
1..1


Scg expression
246075003|Causative agent (attribute)|



Scg expression
< 
105590001|Substance (substance)| OR 
< 373873005|Pharmaceutical / biologic product (product)|



1..11..1


Scg expression
719722006|Has realization (attribute)|



Scg expression
<< 472964009|Allergic process (qualifier value)|


Definition status:  


Scg expression
900000000000073002|Defined (core metadata concept)|

Applies to:

Scg expression
<<< 419199007609328004 |AllergyAllergic todisposition substance (disorderfinding)|


EDITORIAL GUIDELINES for Causative agent (attribute):

Hierarchy

Concept type

Allowed

Exception

Examples and Notes

SubstanceBase substanceyesnone

Allergy concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

  • 294418003 |Allergy to phenol (finding)|

Expected

classification: NEEDS INTERNAL AGREEMENT

classification (Agreed 21-Jan-2020):

  • Classification results are expected to be consistent with the modeling in the Substance hierarchy.
SubstanceModificationnoyes

Example:

293908005 |Allergy to chloral hydrate (finding)|

Chloral hydrate is a sedative and may not be well-represented by "Chloral derivative".

Expected classification

: NEEDS INTERNAL AGREEMENT

(Agreed 21-Jan-2020):

  • Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy. Concepts modeled using a modification should have the concept modeled using the base as an inferred parent if such a concept exists.
    • 782530003 |Allergy to chloral derivative (finding)| will be modeled with Causative agent = 418037002 |Chloral derivative (substance)| and will have the following inferred descendants:
      • 293908005 |Allergy to chloral hydrate (finding)|
SubstanceDisposition grouperyesnone

Example:

  • 294275005 |Allergy to opioid receptor antagonist (finding)|

Expected classification

results: NEEDS INTERNAL AGREEMENT

results (Agreed 21-Jan-2020):

  • Classification results are expected to be consistent with the modeling in the Substance hierarchy
and with other existing concepts in the subhierarchy.ProductDisposition groupernononeNo use case has been identified
  • for
use of this concept type for modeling in this subhierarchy. Disposition groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy.
  • concepts modeled with an attribute value from the Substance hierarchy.
SubstanceStructure
 NEEDS INTERNAL AGREEMENTSubstanceRole groupernonone

Role groupers in the Substance hierarchy will be inactivated in a future release and should not be used for modeling in this subhierarchy. NEEDS INTERNAL AGREEMENT

ProductRole
grouperyesnone

Example:

294367002
  • 782607004 |Allergy to
antiviral agent
  • phenothiazine derivative (finding)|

Expected classification

results: NEEDS INTERNAL AGREEMENT

(Agreed 21-Jan-2020):

  • Classification results are expected to be consistent with the modeling in the Substance
hierarchy and
  • hierarchy and with other existing concepts in the subhierarchy.
  • TBD if there are any restrictions on which product roles can be used in modeling in this subhierarchy
    • Substance
    Structure
    Role grouper
    yesClassification results are expected to be consistent with the modeling
    nonone

    Example:

    • 782607004 |Allergy to phenothiazine derivative (finding)|

    Expected classification: NEEDS INTERNAL AGREEMENT - agreed

    Role groupers in the Substance hierarchy

    and with other existing concepts in the subhierarchy.

    will be inactivated in a future release and should not be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)

    Product
    Structure
    Disposition groupernononeNo use case has been identified for use of this concept
    type for
    type for modeling in this subhierarchy.
     Structure
     Disposition groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy;
    the
     the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy. 
    NEEDS INTERNAL AGREEMENT
    (Agreed 21-Jan-2020)
    Product
    or Substance
    Body system
    Structure groupernonone
    Body system groupers in both the Substance and Product hierarchies will be inactivated in a future release and should no longer

    No use case has been identified for use of this concept type for modeling in this subhierarchy. Structure groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this

    hierarchy

    subhierarchy. 

    NEEDS INTERNAL AGREEMENT

    (Agreed 21-Jan-2020)


    Product
    Medicinal product-containing
    Role grouperyesnone

    Example:

    294522005

    417930000 |Allergy to

    ampicillin and cloxacillin

    adhesive agent (finding)|

    Expected classification results: NEEDS INTERNAL AGREEMENT - to be further discussed with the Drug project re: expected classification
  • 294506009 |Allergy to ampicillin (finding)| with Causative agent = 387170002 |Ampicillin (substance)|
    • 294501004 |Allergy to cloxacillin (finding)| with Causative agent = 373276005 |Cloxacillin (substance)|
    • Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.
    ProductMedicinal product-containingyesnone

    Example:

    • 294522005 |Allergy to ampicillin and cloxacillin (finding)|
    will be modeled with Causative agent = 346320003 |Product containing ampicillin and cloxacillin (medicinal product)| and will have the the following inferred parents:

    Expected classification results: NEEDS INTERNAL AGREEMENT

    • 294650000 |Allergy to vaccine product containing Mumps orthorubulavirus antigen (finding)|

    https://confluence.ihtsdotools.org/display/IAP/Allergy+to+X+vaccine


    ProductMedicinal product-onlynononeNo use case has been identified for use of this concept type for modeling in this subhierarchy.
     NEEDS INTERNAL AGREEMENT - Agreed
    Medicinal product-containing concepts can be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)
    ProductMedicinal product form-containingnononeNo use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product form-containing concepts can be used for modeling in this subhierarchy. 
    NEEDS INTERNAL AGREEMENT - Agreed
    (Agreed 21-Jan-2020)
    ProductMedicinal product form-onlynononeNo use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product form-containing concepts can be used for modeling in this subhierarchy. 
    NEEDS INTERNAL AGREEMENT - Agreed
    (Agreed 21-Jan-2020)
    ProductClinical drugnononeNo use case has been identified for use of this concept
    type 
    type for modeling in this subhierarchy. Medicinal product form-containing concepts can be used for modeling in this subhierarchy. 
    NEEDS INTERNAL AGREEMENT - Agreed
    (Agreed 21-Jan-2020)

    Template language

    Scg expression
    419199007 420134006|AllergyPropensity to substanceadverse reactions (finding)| : [[~1..1 @rolegroup]] { [[~1..1]] 719722006 |Has realization (attribute)| = 472964009 |Allergic process (qualifier value)|, [[~1..1]] 246075003 |Causative agent (attribute)| = [[ +id (< 105590001 |Substance (substance)| OR < 373873005 |Pharmaceutical / biologic product (product)|) @causative]] }

     Misalignment report:

    https://docs.google.com/spreadsheets/d/1CUWI2KYdfjj2MuFTLif1AzCk8BaFYpNN0738F5gJvdk/edit#gid=0

    Rules for description generation:

    1. Remove the semantic tag, e.g. (body structure)
    2. Remove 'Structure of' from [body structure] if term starts with 'Structure of'   e.g. 709530002|Structure of phalanx of hand (body structure)|
    3. Remove 'structure' from [body structure] if term contains 'structure', e.g. 69536005|Head structure (body structure)|   24097009|Bone structure of hand (body structure)|

    JIRA ticket for implementation:

    Jira
    serverIHTSDO JIRA
    serverIdb202d822-d767-33be-b234-fec5accd5d8c
    keyINFRA-11601