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Page properties

Status	Ready for implementation
Version	2.7
Version in PROD	2.0

Descriptions:

Term	description type	Language/acceptability	LangaugeLanguage/acceptability	Case significanceSignificance
Allergy to [substance or product] (finding)	FSN	us:P	gb:P	ci
Allergy to [substance or product]	SYN	us:P	gb:P	ci
[substance or product] allergy	SYN	us:A	gb:A	ci

Concept model:

1*N/A<<<<

Attribute Group Cardinality

Attribute Cardinality

Attribute in Group Cardinality

Attribute

Value

Role group cardinality

1..1

0

..

0

Scg expression
116680003\|Is a (attribute)\|

Scg expression
420134006\|Propensity to adverse reactions (finding)\|

1..1

Scg expression
246075003\|Causative agent (attribute)\|

Scg expression

< 105590001|Substance (substance)| OR

< 373873005

|Pharmaceutical / biologic product (product)|

1..1

Scg expression
719722006\|Has realization (attribute)\|

Scg expression
<< 472964009\|Allergic process (qualifier value)\|

Definition status:

Scg expression
900000000000073002\|Defined (core metadata concept)\|

Applies to:

Scg expression
<<< 419199007609328004 \|AllergyAllergic todisposition substance (disorderfinding)\|

EDITORIAL GUIDELINES for Causative agent (attribute):

Hierarchy

Concept type

Allowed

Exception

Examples and Notes

Substance

Base substance

yes

none

Allergy concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

294418003 |Allergy to phenol (finding)|

Expected

classification: NEEDS INTERNAL AGREEMENT

classification (Agreed 21-Jan-2020):

Classification results are expected to be consistent with the modeling in the Substance hierarchy

and with other existing concepts in the subhierarchy

.

Substance

Modification

no

yes

Example:

293908005 |Allergy to chloral hydrate (finding)|

Chloral hydrate is a sedative and may not be well-represented by "Chloral derivative".

Expected classification

: NEEDS INTERNAL AGREEMENT

(Agreed 21-Jan-2020):

Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy. Concepts modeled using a modification should have the concept modeled using the base as an inferred parent if such a concept exists.
- 782530003 |Allergy to chloral derivative (finding)| will be modeled with Causative agent = 418037002 |Chloral derivative (substance)| and will have the following inferred descendants:
  - 293908005 |Allergy to chloral hydrate (finding)|

Substance

Disposition grouper

yes

none

Example:

294275005 |Allergy to opioid receptor antagonist (finding)|

Expected classification

results: NEEDS INTERNAL AGREEMENT

results (Agreed 21-Jan-2020):

Classification results are expected to be consistent with the modeling in the Substance hierarchy

and with other existing concepts in the subhierarchy.ProductDisposition groupernononeNo use case has been identified for use of this concept type for modeling in this subhierarchy. Disposition groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy. NEEDS INTERNAL AGREEMENT

for concepts modeled with an attribute value from the Substance hierarchy.

Substance

Structure grouper

yes

none

Example:

782607004 |Allergy to phenothiazine derivative (finding)|

Expected classification (Agreed 21-Jan-2020):

Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.

Substance

Role grouper

no

none

Role groupers in the Substance hierarchy will be inactivated in a future release and should not be used for modeling in this subhierarchy.

NEEDS INTERNAL AGREEMENT

(Agreed 21-Jan-2020)

Product

Role SubstanceStructure grouperyesnone

Example:

782607004 |Allergy to phenothiazine derivative (finding)|

Expected classification: NEEDS INTERNAL AGREEMENT

Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.

Disposition grouper

yesnone

Example:

294367002 |Allergy to antiviral agent (finding)|

Expected classification results: NEEDS INTERNAL AGREEMENT

Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.
TBD if there are any restrictions on which product roles can be used in modeling in this subhierarchy

no

none

No use case has been identified for use of this concept type for modeling in this subhierarchy. Disposition groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)

Product

Structure grouper

no

none

No use case has been identified for use of this concept

type for

type for modeling in this subhierarchy.

Structure

Structure groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy.

NEEDS INTERNAL AGREEMENT

(Agreed 21-Jan-2020)

Product

or Substance

Body system

Role grouper

no

yes

none

Body system groupers in both the Substance and Product hierarchies will be inactivated in a future release and should no longer be used for modeling in this hierarchy. NEEDS INTERNAL AGREEMENT

Example:

417930000 |Allergy to adhesive agent (finding)|

Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.

Product

Medicinal product-containing

yes

none

Example:

294522005 |Allergy to ampicillin and cloxacillin (finding)|

Expected classification results:

NEEDS

NEEDS INTERNAL AGREEMENT

294522005

294506009 |Allergy to ampicillin (finding)| with Causative agent = 387170002 |Ampicillin (substance)|

294501004 |Allergy to cloxacillin (finding)| with Causative agent = 373276005 |Cloxacillin (substance)|

294650000 |Allergy to

ampicillin and cloxacillin (finding)| will be modeled with Causative agent = 346320003 |Product containing ampicillin and cloxacillin (medicinal product)| and will have the the following inferred parents:

vaccine product containing Mumps orthorubulavirus antigen (finding)|

https://confluence.ihtsdotools.org/display/IAP/Allergy+to+X+vaccine


Product	Medicinal product-only	no	none	No use case has been identified for use of this concept type for modeling in this subhierarchy.

NEEDS INTERNAL AGREEMENT

Medicinal product-containing concepts can be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)
Product	Medicinal product form-containing

yes

no

none

No use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product form-containing concepts can be used for modeling in this subhierarchy.

NEEDS INTERNAL AGREEMENT

(Agreed 21-Jan-2020)
Product	Medicinal product form-only	no	none	No use case has been identified for use of this concept type for modeling in this subhierarchy.

NEEDS INTERNAL AGREEMENT

Medicinal product form-containing concepts can be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)
Product	Clinical drug	no	none	No use case has been identified for use of this concept

type

type for modeling in this subhierarchy. Medicinal product form-containing concepts can be used for modeling in this subhierarchy.

NEEDS INTERNAL AGREEMENT

(Agreed 21-Jan-2020)

Template language

Scg expression

419199007 420134006|AllergyPropensity to substanceadverse reactions (finding)| : [[~1..1 @rolegroup]] { [[~1..1]] 719722006 |Has realization (attribute)| = 472964009 |Allergic process (qualifier value)|, [[~1..1]] 246075003 |Causative agent (attribute)| = [[ +id (< 105590001 |Substance (substance)| OR < 373873005 |Pharmaceutical / biologic product (product)|) @causative]] }

Misalignment report:

https://docs.google.com/spreadsheets/d/1CUWI2KYdfjj2MuFTLif1AzCk8BaFYpNN0738F5gJvdk/edit#gid=0

Rules for description generation:

Remove the semantic tag, e.g. (body structure)
Remove 'Structure of' from [body structure] if term starts with 'Structure of' e.g. 709530002|Structure of phalanx of hand (body structure)|
Remove 'structure' from [body structure] if term contains 'structure', e.g. 69536005|Head structure (body structure)| 24097009|Bone structure of hand (body structure)|

JIRA ticket for implementation:

Jira

server	IHTSDO JIRA
serverId	b202d822-d767-33be-b234-fec5accd5d8c
key	INFRA-11601

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Descriptions:

Concept model:

Definition status:

Applies to:

EDITORIAL GUIDELINES for Causative agent (attribute):

Template language

Misalignment report:

Rules for description generation:

JIRA ticket for implementation: