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StatusIn progressReady for implementation
Version

1.0.1


Descriptions:

Termdescription typeLanguage/acceptabilityLangaugeLanguage/acceptabilityCase significance

[Accidental/Intentional] [course] [substance or product] overdose (disorder)

FSNus:Pgb:Pci

[Accidental/Intentional] [course] [substance or product] overdose

SYNus:Pgb:Pci

Concept model:

Attribute Group CardinalityAttribute cardinalityCardinalityAttribute cardinality in role groupGroup CardinalityAttributeValue
10..010..01


Scg expression
116680003 |Is a (attribute)|



Scg expression
1149222004 |Overdose (disorder)|


0..1
0..1


Scg expression
263502005 |Clinical course (attribute)|



Scg expression
< 288524001 |Courses (qualifier value)|


0..1
0..1


Scg expression
42752001 |Due to (attribute)|



Scg expression
<< 1148742001 |Intentional event (event)| OR << 418019003 |Accidental event (event)|


0..*1
0..1


Scg expression
246075003|Causative agent (attribute)|



Scg expression
[agent] << 105590001|Substance (substance)| OR << 373873005|Pharmaceutical / biologic product (product)|


...

Scg expression
1149222004 |Overdose (disorder)|: 
[[~0..1]] {[[~0..1]] 263502005 |Clinical course (attribute)| = [[ +id ( < 288524001 |Courses (qualifier value)|) @course]]}, 
[[~0..1]] {[[~0..1]] 42752001 |Due to (attribute)| = [[+id ( << 1148742001 |Intentional event (event)| OR << 418019003 |Accidental event (event)|) @dueto ]]}, 
[[~0..*1]] {[[~0..1]] 246075003 |Causative agent (attribute)| = [[+id ( < 105590001 |Substance (substance)| OR < 373873005 |Pharmaceutical / biologic product (product)|) @causative]]}

Link to the misaligned concept report

Overdose misaligned concept report 2021-Dec-14

Rules for generating descriptions:

...

HierarchyConcept typeAllowedExceptionExamples and Notes (Note: Examples are existing concepts and may not reflect the terming patterns described in the template.)
SubstanceBaseyesn/a

Example:

  • 295184007 |Morphine overdose (disorder)|
SubstanceModificationyesyes

Concepts representing substance modifications are exceptions and may be included if the overdose profile is significantly different from the substance base.

Exception examples:

  • Liposome or lipid complex substances (e.g. 412088006 |Amphotericin B liposome (substance)|, 426490000 |Vincristine liposome (substance)|)
  • Pegylated substance (e.g. 385544005 |Pegfilgrastim (substance)|, 770965008 |Pegvaliase (substance)|)
  • Salt forms (e.g. 273948005 |Chloral hydrate (substance)|, 396063006 |Fluphenazine decanoate (substance)|)

Example:

  • 296136008 |Chloral hydrate overdose (disorder)|
  • 296213007 |Fluphenazine decanoate overdose (disorder)|
Multiple substanceyes

Overdose concepts representing multiple substances should be modeled using a GCIs, with Causative agent that is a descendant of 105590001 |Substance (substance)|; preferentially modeling with the base rather than a modification unless the overdose profile is significantly different from the substance base.

Example:

  • 1149374003 |Dextropropoxyphene and/or paracetamol overdose (disorder)|
  • 1149371006 |Sulfamethoxazole and/or trimethoprim overdose (disorder)|
SubstanceDisposition grouperyesn/a

Overdose concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

  • 297053006 |Overdose of angiotensin-converting-enzyme inhibitors (disorder)|
  • 296515004 |Opiate antagonist overdose (disorder)|
SubstanceRole grouperyesn/a

Overdose concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release.

Example:

  • 297006008 |Diuretic overdose (disorder)|
  • 295217003 |Non-steroidal anti-inflammatory overdose (disorder)|
SubstanceStructure grouperyesn/a

Overdose concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

  • 295188005 |Pethidine analog overdose (disorder)|
  • 1155996000 |Phenothiazine and/or phenothiazine derivative overdose (disorder)|

Expected classification:

  • Classification results are expected to be consistent with the Substance hierarchy and with other existing concepts in the subhierarchy.
ProductStructure groupernon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductDisposition groupernon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductRole groupernon/a

Overdose concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release.

ProductMedicinal product-containingnon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductMedicinal product-onlynon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductMedicinal product form-containingnon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
Product

Medicinal product form-only

non/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductClinical drugnon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.

...

  1. For the FSN, align terming and case sensitivity with the FSN for the concept that is selected as the attribute value, excluding the semantic tag. 
  2. For the PT, align terming and case sensitivity with the US and GB PT for the concept that is selected as the attribute value.
  3. In cases where neither the US or GB PT matches the FSN, excluding the semantic tag, a synonym corresponding to the FSN is required unless explicitly identified as an exception.Additional synonyms "[agent] adverse reaction" should be added.

JIRA ticket for implementation:

Jira
serverIHTSDO JIRA
serverIdb202d822-d767-33be-b234-fec5accd5d8c
keyINFRA-8098