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StatusIn progressReady for implementation
Version

1.0.1


Descriptions:

Termdescription typeLanguage/acceptabilityLangaugeLanguage/acceptabilityCase significance

[Accidental/Intentional] [course] [substance or product] overdose (disorder)

FSNus:Pgb:Pci
Overdose

[Accidental/Intentional] [course] [substance or product] overdose

SYNus:Pgb:Pci

Concept model:

Attribute Group CardinalityAttribute CardinalityAttribute in Group CardinalityAttributeValue
Role group numberRole group cardinality
0..01..1


Scg expression
116680003 |Is a (attribute)|



Scg expression
1149222004 |Overdose (disorder)|


0
n/a
..1
0..1


Scg expression
246075003
263502005 |
Causative
Clinical 
agent
course (attribute)|



Scg expression
[agent]
< 
<<
288524001 
105590001
|
Substance
Courses (
substance)| OR << 373873005 |Pharmaceutical / biologic product (product
qualifier value)|


0
0
..1
0..1


Scg expression
42752001 |Due to (attribute)|



Scg expression
< 272379006 |Event
<< 1148742001 |Intentional event (event)| OR << 418019003 |Accidental event (event)|


0
0
..1
0..1


Scg expression
263502005
246075003|
Clinical
Causative 
course
agent (attribute)|



Scg expression
<  288524001 |Courses (qualifier value)|
00..1
[agent] << 105590001|Substance (substance)| OR << 373873005|Pharmaceutical / biologic product (product)|


Definition status:  

Scg expression
900000000000073002|Defined (core metadata concept)|

...

Applies to:

Scg expression
<< 1149222004 |Overdose (disorder)|

Template Language

Scg expression
1149222004 |Overdose (disorder)|: 
[[~0..1]] {[[~0..1]] 263502005 |Clinical course (attribute)| = [[ +id ( < 288524001 |Courses (qualifier value)|) @course]]}, 
[[~0..1]] {[[~0..1]] 42752001 |Due to (attribute)| = [[+id ( << 1148742001 |Intentional event (event)| OR << 418019003 |Accidental event (event)|) @dueto ]]}, 
[[~0..1]] {[[~0..1]] 246075003 |Causative agent (attribute)| = [[+id ( < 105590001 |Substance (substance)| OR < 373873005 |Pharmaceutical / biologic product (product)|) @causative]]}

Link to the misaligned concept report

Overdose misaligned concept report 2021-Dec-14

Rules for generating descriptions:

  1. Apply General rules for generating descriptions for templates

Editorial guidelines for selection of Causative agent attribute value:

The following editorial guidelines apply to concepts in the International Release; editorial guidelines for concepts in national extensions may vary.

HierarchyConcept
Causative agent
typeAllowedExceptionExamples and Notes (Note: Examples are existing concepts and may not reflect the terming patterns described in the template.)
Substance
base
Baseyes
Overdose concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.Substance modificationno, unless documented as exceptionOverdose concepts representing a substance modification should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.
n/a

Example:

  • 295184007 |Morphine overdose (disorder)|

Expected classification:

  • Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy.
SubstanceModificationyesyes

Concepts representing substance modifications are exceptions and may be included if the overdose profile is significantly different from the substance base.

Exception examples:

  • Chemical element with multiple modifications (e.g. 422232005 |Calcium lactate gluconate (substance)|)
    • Liposome or lipid complex substances (e.g. 412088006 |Amphotericin B liposome (substance)|, 426490000 |Vincristine liposome (substance)|)
    • Pegylated substance (e.g. 385544005 |Pegfilgrastim (substance)|, 770965008 |Pegvaliase (substance)|)
    • Salt forms (e.g. 273948005 |Chloral hydrate (substance)|
    )

    Example:

    296213007
    • , 396063006 |Fluphenazine decanoate
    overdose
    • (
    disorder
    • substance)
    |296217008
    • |
    Fluphenazine enanthate overdose (disorder
    • )
    |

    Expected classification:

    • Classification results are expected to reflect that the concept modeled with the modified substance is a descendant of the concept modeled with the base substance (if such a concept exists.
    Multiple substanceyes

    Adverse reaction concepts representing multiple substances should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|; preferentially modeling with the base rather than a modification unless the adverse reaction profile is significantly different from the substance base.

    Example:

    292984002 |Ampicillin and cloxacillin adverse reaction
    • 296136008 |Chloral hydrate overdose (disorder)|
    292987009 |Piperacillin and tazobactam adverse reaction

    Expected classification (Agreed 21-Jan-2020):

    Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the
    • 296213007 |Fluphenazine decanoate overdose (disorder)|
  • 292989007 |Ticarcillin and clavulanic acid adverse reaction (disorder)|
  • Substance
    hierarchy.
    Disposition grouperyesn/a

    Overdose concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

    Example:

    • 297053006 |Overdose of angiotensin-converting-enzyme inhibitors (disorder)|
    • 296515004 |Opiate antagonist overdose (disorder)|
    Expected classification results:
    Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the
    Substance
    hierarchy.
    Role grouperyesn/a

    Overdose concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

    Note that role Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the

    Role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release.

    Example:

    • 297006008 |Diuretic overdose (disorder)|
    • 295217003 |Non-steroidal anti-inflammatory overdose (disorder)|

    Expected classification results (to be revised when concepts are remodeled using Medicinal product ):

    Substance
    hierarchy.
    Structure grouperyesn/a

    Overdose concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

    Example:

    218638005 |Adverse reaction caused by hydantoin derivative
    • 295188005 |Pethidine analog overdose (disorder)|
  • 419885006 |Beta lactam adverse reaction (disorder)|
  • Expected classification (Agreed 21-Jan-2020):

    • Classification results are expected to be consistent with the Substance hierarchy and with other existing concepts in the subhierarchy.
    • 1155996000 |Phenothiazine and/or phenothiazine derivative overdose (disorder)|
    ProductStructure groupernon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
    ProductDisposition groupernon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
    ProductRole groupernon/a

    Overdose concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release.

    ProductMedicinal product-containingnon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
    ProductMedicinal product-onlynon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
    ProductMedicinal product form-containingnon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
    Product

    Medicinal product form-only

    non/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
    ProductClinical drugnon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
    Descendant of 373873005 |Pharmaceutical / biologic product (product)|no, unless documented as exceptionExceptions: None identified

    The following types of groupers are out of scope; existing concepts have been inactivated or will be addressed in future release:

    • Groupers based on more than one role (e.g. 292722006 |Chelating agents and antidotes adverse reaction (disorder)|)
    • Groupers based on body system or intended site or route of administration (e.g. 292548001 |Drug groups primarily affecting respiratory system adverse reaction (disorder)|) or 417895009 |Topical agent adverse reaction (disorder)|)
    • Groupers based on disposition, role, or structure combined with an individual substance (e.g. 287177000 |Sulfonamide/trimethoprim reaction (disorder)| or 292513008 |Methyldopa and diuretic adverse reaction (disorder)|)
    • Groupers based on "combined" or "compound" substances (e.g. 292983008 |Combined penicillin preparation adverse reaction (disorder)| or 293358005 |Compound iron preparations adverse reaction (disorder)|)
    • Groupers based on disposition or structure combined with intended site or route of administration (e.g. 433494006 |Adverse effect of oral diphosphonate (disorder)|)
    • Groupers based on disposition combined with role (e.g. 292265006 |Dopaminergic drug used in parkinsonism adverse reaction (disorder)|)

    Rules for description generation:

    1. For the FSN, align terming and case sensitivity with the FSN for the concept that is selected as the attribute value, excluding the semantic tag. 
    2. For the PT, align terming and case sensitivity with the US and GB PT for the concept that is selected as the attribute value.
    3. In cases where neither the US or GB PT matches the FSN, excluding the semantic tag, a synonym corresponding to the FSN is required unless explicitly identified as an exception.
    4. Additional synonyms "[agent] adverse reaction" should be added. Other synonyms are not allowed unless explicitly identified as an exception.

    JIRA ticket for implementation:

    Jira
    serverIHTSDO JIRA
    serverIdb202d822-d767-33be-b234-fec5accd5d8c
    keyINFRA-8098