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StatusIn progress
Version

0.5


Descriptions:

Termdescription typeLanguage/acceptabilityLangaugeLanguage/acceptabilityCase significance

Anaphylaxis caused by [agent] (disorder)

FSNus:Pgb:Pci

Anaphylaxis caused by [agent]

SYNus:Pgb:Pci

Concept model:

769260004Immunoglobulin E-mediated allergic
Attribute CardinalityAttributeValuerole group numberRole group cardinality
1..1


Scg expression
116680003|Is a (attribute)|



Scg expression
39579001 |Anaphylaxis (disorder)|


0N/A
1..1


Scg expression
263502005 |Clinical course (attribute)|



Scg expression
385315009 |Sudden onset (qualifier value)|


0
1..1


Scg expression
308489006 |Pathological process (qualifier value)|



Scg expression
472964009 |
Allergic process (qualifier value)|





1

1..11..1



Scg expression
246075003|Causative agent (attribute)|



Scg expression
[agent] << 105590001|Substance (substance)| OR << 373873005|Pharmaceutical / biologic product (product)|


Definition status:  

Scg expression
900000000000073002|Defined (core metadata concept)|

Template Language

281647001 39579001 |Adverse reaction Anaphylaxis (disorder)|: [[~1..1]] { [[~0~1..1]] 363698007 370135005 |Finding site Pathological process (attribute)|= [[+id(< 123037004 |Body structure (body structure472964009 |Allergic process (qualifier value)|) @site ]], [[~1..1]] 246075003 |Causative agent (attribute)| = [[+id( <<  105590001 |Substance (substance)|  OR <<  373873005 |Pharmaceutical / biologic product (product)|  OR <<  260787004 |Physical object (physical object)|  OR <<  78621006 |Physical force (physical force)|) @agent]] }

Applies to:

Scg expression
<< 282100009417516000 |Adverse reactionAnaphylaxis caused by substance (disorder)|

Editorial guidelines for selection of Causative agent attribute value:

The following editorial guidelines apply to concepts in the International Release; editorial guidelines for concepts in national extensions may vary.

Concept typeAllowedExamples and Notes (Note: Examples are existing concepts and may not reflect the terming patterns described in the template.)
Substance baseyes
Adverse reaction concepts

Concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

292392003 |Fluphenazine adverse reaction
  • 241939002 |Insulin-induced anaphylaxis (disorder)|

Expected classification

(Agreed 21-Jan-2020)

:

  • Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy.
Substance modification
yes, only if identified as accepted exception

Adverse reaction concepts representing a substance modification should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Concepts representing substance modifications are exceptions and may be included if the adverse reaction profile is significantly different from the substance base.

Exception examples:

  • Chemical element with multiple modifications (e.g. 422232005 |Calcium lactate gluconate (substance)|)
  • Liposome or lipid complex substances (e.g. 412088006 |Amphotericin B liposome (substance)|, 426490000 |Vincristine liposome (substance)|)
  • Pegylated substance (e.g. 385544005 |Pegfilgrastim (substance)|, 770965008 |Pegvaliase (substance)|)
  • Salt forms (e.g. 412432007 |Metoprolol succinate (substance)|, 72770009 |Metoprolol tartrate (substance)|)

Example:

  • 292389002 |Fluphenazine decanoate adverse reaction (disorder)|
  • 292390006 |Fluphenazine enanthate adverse reaction (disorder)|

Expected classification (Agreed 21-Jan-2020):

  • Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy.
no, unless documented as exception

Exceptions: None identified

Multiple substanceno, unless documented as exception

Exceptions: None identified

Disposition grouperno, unless documented as exception

Exceptions: None identified

Role grouperno, unless documented as exception

Exceptions: None identified

Structure grouperno, unless documented as exception

Exceptions: None identified

Descendant of 373873005 |Pharmaceutical / biologic product (product)|no, unless documented as exceptionExceptions: None identified
Multiple substanceyes

Adverse reaction concepts representing multiple substances should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|; preferentially modeling with the base rather than a modification unless the adverse reaction profile is significantly different from the substance base.

Example:

  • 292984002 |Ampicillin and cloxacillin adverse reaction (disorder)|
  • 292987009 |Piperacillin and tazobactam adverse reaction (disorder)|
  • 292989007 |Ticarcillin and clavulanic acid adverse reaction (disorder)|

Expected classification (Agreed 21-Jan-2020):

  • Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy.
Disposition grouperyes

Adverse reaction concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

  • 293432006 |3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor adverse reaction (disorder)|
  • 870376001 |Adverse reaction to dopamine receptor agonist (disorder)|

Expected classification results (Agreed 21-Jan-2020):

  • Classification results are expected to be consistent with the modeling in the Substance hierarchy for concepts modeled with an attribute value from the Substance hierarchy.
Role grouperno

Adverse reaction concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Note that role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release.

Example:

  • 430136001 |Adverse reaction caused by antiparkinsonism drug (disorder)|
  • 292040004 |Analgesic adverse reaction (disorder)|

Expected classification results (Agreed 21-Jan-2020):

  • Classification results are expected to be consistent with the modeling in the Substance hierarchy for concepts modeled with an attribute value from the Substance hierarchy.
Structure grouperyes

Adverse reaction concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

  • 218638005 |Adverse reaction caused by hydantoin derivative (disorder)|
  • 419885006 |Beta lactam adverse reaction (disorder)|

Expected classification (Agreed 21-Jan-2020):

Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.

Rules for description generation:

  1. For the FSN, align terming and case sensitivity with the FSN for the concept that is selected as the attribute value, excluding the semantic tag. 
  2. For the PT, align terming and case sensitivity with the US and GB PT for the concept that is selected as the attribute value.
  3. In cases where neither the US or GB PT matches the FSN, excluding the semantic tag, a synonym corresponding to the FSN is required unless explicitly identified as an exception.Additional synonyms "[agent] adverse reaction" should be added. Other synonyms are not allowed unless explicitly identified as an exception.

JIRA ticket for implementation: