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Descriptions:

Concept model:

...

...

Attribute Cardinality	Attribute	Value

...

Role group cardinality
1..*	Scg expression 116680003|Is a (attribute)|	Scg expression 420134006|Propensity to adverse reactions (finding)|

...

	N/A
1..1	Scg expression 246075003|Causative agent (attribute)|	[substance]

 

Scg expression

...

<<105590001|Substance (substance)|

...

	1..1
1..1		Scg expression 719722006|Has realization (attribute)|	Scg expression 472964009|Allergic process (qualifier value)|

...

Definition status:  

900000000000073002|Defined (core metadata concept)|

Applies to:

<< 419199007 |Allergy to substance (disorder)|

Template language

419199007 |Allergy to substance (finding)| : [[~1..1 @rolegroup]] { [[~1..1]] 719722006 |Has realization (attribute)| = 472964009 |Allergic process (qualifier value)|, [[~1..1]] 246075003 |Causative agent (attribute)| = [[ +id (<< 105590001 |Substance (substance)| ) @causative]] }

Misalignment report:

https://docs.google.com/spreadsheets/d/1CUWI2KYdfjj2MuFTLif1AzCk8BaFYpNN0738F5gJvdk/edit#gid=0

Rules for description generation:

1. Remove the semantic tag, e.g. (body structure)
2. Remove 'Structure of' from [body structure] if term starts with 'Structure of'   e.g. 709530002|Structure of phalanx of hand (body structure)|
3. Remove 'structure' from [body structure] if term contains 'structure', e.g. 69536005|Head structure (body structure)|   24097009|Bone structure of hand (body structure)|

JIRA ticket for implementation:

Exceptions:

There are few exceptions in modeling the causative agent attribute for descendants of the 419199007 |Allergy to substance (finding)| in comparison to the general template guidelines:

• 788802000|Allergy to cetuximab (finding)|
  • The allergy is to alpha-gal substance in a product containing cetuximab.
• 432807008 |Pollen-food allergy (finding)|
  • This is a contact food allergy that occurs in patients with pollen allergy when ingesting raw fruits, vegetables and some tree nuts. Symptoms are caused by a heat-labile protein in fruits, vegetables, and nuts that cross-reacts with proteins in aeroallergens.
• 293908005 |Allergy to chloral hydrate (finding)|
  • In general, concepts in the 419199007 |Allergy to substance (finding)| sub-hierarchy are modeled with the base substance and not its modification. Chloral hydrate is an exception to this rule.

Please note that for the first two:  since it is hard to fully define these concepts, they have been left as primitive concepts.