Page properties |
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Status | In progressReady for implementation |
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Version | 1.0.1 |
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Descriptions:
Term | description type | Language/acceptability | LangaugeLanguage/acceptability | Case significance |
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[Accidental/Intentional] [course] [substance or product] overdose (disorder) | FSN | us:P | gb:P | ci |
[Accidental/Intentional] [course] [substance or product] overdose | SYN | us:P | gb:P | ci |
Concept model:
Attribute Group Cardinality | Attribute Cardinality | Attribute in Group Cardinality | Attribute | Value |
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Role group number | Role group cardinality | 0..0 | 1..1 |
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Scg expression |
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116680003 |Is a (attribute)| |
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NEWCONCEPT ""n/a | n/a | 1246075003Causativeagent[agent]<<105590001Substancesubstance)| OR << 373873005|Pharmaceutical / biologic product (product)|0 |
0..1 |
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Scg expression |
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42752001 |Due to (attribute)| |
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[due to] < 272379006 |Event<< 1148742001 |Intentional event (event)| OR << 418019003 |Accidental event (event)| |
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0263502005 Clinicalcourseclinical course<288524001Coursesqualifier value)|0 | 0..1substance)| OR << 373873005|Pharmaceutical / biologic product (product)| |
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Definition status:
Scg expression |
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900000000000073002|Defined (core metadata concept)| |
Template Language
Applies to:
Scg expression |
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<< 1149222004 NEW CONCEPT "Overdose (disorder)"|Overdose (disorder)| |
Template Language
Scg expression |
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1149222004 |Overdose (disorder)|:
[[~0..1]] {[[~0..1]] 263502005 |Clinical course (attribute)| = [[ +id ( < 288524001 |Courses (qualifier value)|) @course]]},
[[~0..1]] {[[~0..1]] 42752001 |Due to (attribute)| = [[+id ( << 1148742001 |Intentional event (event)| OR << 418019003 |Accidental event (event)|) @dueto ]]},
[[~0..1]] {[[~0..1]] 246075003 |Causative agent (attribute)| = [[+id ( < 105590001 |Substance (substance)| OR < 373873005 |Pharmaceutical / biologic product (product)|) @causative]]} |
Link to the misaligned concept report
Overdose misaligned concept report 2021-Dec-14
Rules for generating descriptions:
- Apply General rules for generating descriptions for templates
Editorial guidelines for selection of Causative agent attribute value:
The following editorial guidelines apply to concepts in the International Release; editorial guidelines for concepts in national extensions may vary.
Causative agent type | Allowed | Exception | Examples and Notes (Note: Examples are existing concepts and may not reflect the terming patterns described in the template.) |
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Substance |
baseOverdose concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.292392003 |Fluphenazine adverse reaction Substance modification | no, unless documented as exception | Overdose concepts representing a substance modification should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. - 295184007 |Morphine overdose (disorder)|
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Expected classification:
- Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy.
Substance | Modification | yes | yes |
Concepts representing substance modifications are exceptions and may be included if the overdose profile is significantly different from the substance base. Exception examples: |
Chemical element with multiple modifications (e.g. 422232005 |Calcium lactate gluconate (substance)|)- Liposome or lipid complex substances (e.g. 412088006 |Amphotericin B liposome (substance)|, 426490000 |Vincristine liposome (substance)|)
- Pegylated substance (e.g. 385544005 |Pegfilgrastim (substance)|, 770965008 |Pegvaliase (substance)|)
- Salt forms (e.g.
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412432007 Metoprolol succinate - Chloral hydrate (substance)|,
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72770009 Metoprolol tartrate - Fluphenazine decanoate (substance)|)
Example: |
292389002 |Fluphenazine decanoate adverse reaction - 296136008 |Chloral hydrate overdose (disorder)|
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292390006 enanthate adverse reaction - decanoate overdose (disorder)|
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Expected classification:
- Classification results are expected to reflect that the concept modeled with the modified substance is a descendant of the concept modeled with the base substance (if such a concept exists (e.g. 292389002 |Fluphenazine decanoate adverse reaction (disorder)| has inferred parent 292392003 |Fluphenazine adverse reaction (disorder)|).
Multiple substance | yes | Adverse reaction concepts representing multiple substances Substance | Disposition grouper | yes | n/a | Overdose concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Example: - 297053006 |Overdose of angiotensin-converting-enzyme inhibitors (disorder)|
- 296515004 |Opiate antagonist overdose (disorder)|
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Substance | Role grouper | yes | n/a | Overdose concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)| |
; preferentially modeling with the base rather than a modification unless the adverse reaction profile is significantly different from the substance base. Role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release. Example: |
292984002 |Ampicillin and cloxacillin adverse reaction 292989007 |Ticarcillin and clavulanic acid adverse reaction - 297006008 |Diuretic overdose (disorder)|
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292987009 |Piperacillin and tazobactam adverse reaction (disorder)|- 295217003 |Non-steroidal anti-inflammatory overdose (disorder)|
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Expected classification (Agreed 21-Jan-2020):Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the hierarchy.Disposition Adverse reaction n/a | Overdose concepts representing a |
disposition structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Example: |
293432006 |3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor adverse reaction - 295188005 |Pethidine analog overdose (disorder)|
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870376001 |Adverse reaction to dopamine receptor agonist - 1155996000 |Phenothiazine and/or phenothiazine derivative overdose (disorder)|
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Expected classification results:
- Classification results are expected to reflect that the adverse reaction concepts are descendants of the appropriate disposition grouper based on the modeling of the 726542003 |Has disposition (attribute)| attribute in the substance hierarchy (e.g. 292113001 |Lansoprazole adverse reaction (disorder)| has inferred parent 292111004 |Proton pump inhibitor adverse reaction (disorder)|).
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Product | Structure grouper | no | n/a | No use case has been identified for use of this concept type for modeling in this subhierarchy. |
Product | Disposition grouper | no | n/a | No use case has been identified for use of this concept type for modeling in this subhierarchy. |
Product | Role grouper | no | n/a | Overdose |
Role grouper | yes | Adverse reaction concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. |
Note that role Role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release. |
Example:
- 430136001 |Adverse reaction caused by antiparkinsonism drug (disorder)|
- 292040004 |Analgesic adverse reaction (disorder)|
Expected classification results (Agreed 21-Jan-2020):
Classification results are expected to reflect that the adverse reaction concepts are descendants of the appropriate disposition grouper based on the modeling of the 726542003 |Has disposition (attribute)| attribute in the substance hierarchy (e.g. 292113001 |Lansoprazole adverse reaction (disorder)| has inferred parent 292111004 |Proton pump inhibitor adverse reaction (disorder)|).Classification results are expected to be consistent with the modeling in the Substance hierarchy for concepts modeled with an attribute value from the Substance hierarchy.Product | Medicinal product-containing | no | n/a | No use case has been identified for use of this concept type for modeling in this subhierarchy. |
Product | Medicinal product-only | no | n/a | No use case has been identified for use of this concept type for modeling in this subhierarchy. |
Product | Medicinal product form-containing | no | n/a | No use case has been identified for use of this concept type for modeling in this subhierarchy. |
Product | Medicinal product form-only | no | n/a | No use case has been identified for use of this concept type for modeling in this subhierarchy. |
Product | Clinical drug | no | n/a | No use case has been identified for use of this concept type for modeling in this subhierarchy. |
Structure grouper | yes | Adverse reaction concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Example: - 218638005 |Adverse reaction caused by hydantoin derivative (disorder)|
- 419885006 |Beta lactam adverse reaction (disorder)|
Expected classification (Agreed 21-Jan-2020): - Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.
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Descendant of 373873005 |Pharmaceutical / biologic product (product)| | no, unless documented as exception | Exceptions: None identified The following types of groupers are out of scope; existing concepts have been inactivated or will be addressed in future release:
- Groupers based on more than one role (e.g. 292722006 |Chelating agents and antidotes adverse reaction (disorder)|)
- Groupers based on body system or intended site or route of administration (e.g. 292548001 |Drug groups primarily affecting respiratory system adverse reaction (disorder)|) or 417895009 |Topical agent adverse reaction (disorder)|)
- Groupers based on disposition, role, or structure combined with an individual substance (e.g. 287177000 |Sulfonamide/trimethoprim reaction (disorder)| or 292513008 |Methyldopa and diuretic adverse reaction (disorder)|)
- Groupers based on "combined" or "compound" substances (e.g. 292983008 |Combined penicillin preparation adverse reaction (disorder)| or 293358005 |Compound iron preparations adverse reaction (disorder)|)
- Groupers based on disposition or structure combined with intended site or route of administration (e.g. 433494006 |Adverse effect of oral diphosphonate (disorder)|)
- Groupers based on disposition combined with role (e.g. 292265006 |Dopaminergic drug used in parkinsonism adverse reaction (disorder)|)
Rules for description generation:
- For the FSN, align terming and case sensitivity with the FSN for the concept that is selected as the attribute value, excluding the semantic tag.
- For the PT, align terming and case sensitivity with the US and GB PT for the concept that is selected as the attribute value.
- In cases where neither the US or GB PT matches the FSN, excluding the semantic tag, a synonym corresponding to the FSN is required unless explicitly identified as an exception.Additional synonyms "[agent] adverse reaction" should be added. Other synonyms are not allowed unless explicitly identified as an exception.
JIRA ticket for implementation:
Jira |
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server | IHTSDO JIRA |
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serverId | b202d822-d767-33be-b234-fec5accd5d8c |
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key | INFRA-8098 |
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