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  1. Remove the semantic tag, (substance)       
  2. Substances are the 'source of truth' so an alternate Preferred Term (PT) must always be added for all concepts when there are dialect variations in spellings for US/GB (language acceptability P/A) and vice versa
  3. Align case sensitivity with substance term for FSN (ci or cI) and PT (ci, CS or cI)
  4. For content in the International Release, Has active ingredient (attribute)| should represent the base ingredient, not a modification, unless explicitly identified as an exception.

    • Exceptions:
      • Liposome substances (e.g. 426490000 |Vincristine liposome (substance)|)
      • Lipid complex substances (e.g. 425953004 |Amphotericin B lipid complex (substance)|)
      • Phospholipid complex substances (e.g. 768664009 |Amphotericin B phospholipid complex (substance)|)
      • Cholesteryl complex substances (e.g. 427544000 |Amphotericin B cholesteryl sulfate complex (substance)|)
      • Calcium lactate gluconate


JIRA ticket for implementation:

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