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Hierarchy | Concept type | Allowed | Exception | Examples and Notes |
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| Substance | Base | yes | none | Concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Examples:
Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy. |
| Substance | Modification | no | none | No use case has been identified for use of this concept type for modeling in this subhierarchy. |
| Substance | Structure grouper | yes | none | Concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.
Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy. |
| Substance | Disposition grouper | yes | none | Concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.
Classification results are expected to reflect that the adverse reaction concepts are descendants of the appropriate disposition grouper based on the modeling of the 726542003 |Has disposition (attribute)| attribute in the substance hierarchy. |
| Substance | Role grouper | no | none | Concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.
Classification results are expected to reflect that the adverse reaction concepts are descendants of the appropriate disposition grouper based on the modeling of the 726542003 |Has disposition (attribute)| attribute in the substance hierarchy.Role groupers in the Substance hierarchy will be inactivated in a future release and should not be used for modeling in this subhierarchy. (Agreed 21-Jan-2020) |
| Product | Medicinal product-containing | yes | none | Examples to be added - pending implementation of roles and products as causative agents |
| Product | Role grouper | yes | none | Examples to be added - pending implementation of roles and products as causative agents |
| Product | Structure grouper | no | none | No use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product-containing concepts can be used for modeling in this subhierarchy. |
| Product | Disposition grouper | no | none | No use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product-containing concepts can be used for modeling in this subhierarchy. |
| Product | Medicinal product-only | no | none | No use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product-containing concepts can be used for modeling in this subhierarchy. |
| Product | Medicinal product form-containing | no | none | No use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product-containing concepts can be used for modeling in this subhierarchy. |
| Product | Medicinal product form-only | no | none | No use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product-containing concepts can be used for modeling in this subhierarchy. |
| Product | Clinical drug | no | none | No use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product-containing concepts can be used for modeling in this subhierarchy. |
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