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Poisoning concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Examples:

• 13503000 |Poisoning caused by naloxone (disorder)|
• 30138004 |Poisoning caused by ether (disorder)|

Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy.

Poisoning concepts representing a substance modification should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Concepts representing substance modifications are exceptions and may be included if the poisoning profile is significantly different from the substance base.

Exception examples:

• Chemical element with multiple modifications (e.g. 422232005 |Calcium lactate gluconate (substance)|
• Liposome or lipid complex substances (e.g. 412088006 |Amphotericin B liposome (substance)|, 426490000 |Vincristine liposome (substance)|)
• Pegylated substance (e.g. 385544005 |Pegfilgrastim (substance)|, 770965008 |Pegvaliase (substance)|)
• Salt forms (e.g. 273948005 |Chloral hydrate (substance)|, 396063006 |Fluphenazine decanoate (substance)|)

Examples of exception:

• 62942003 |Tetraethyl pyrophosphate poisoning (disorder)|

Poisoning concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Examples:

• 1153528004 |Poisoning caused by substance with ether structure (disorder)|

Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy.

Poisoning concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Examples:

• 9291000 |Poisoning caused by monoamine oxidase inhibitor (disorder)|

Classification results are expected to reflect that the adverse reaction concepts are descendants of the appropriate disposition grouper based on the modeling of the 726542003 |Has disposition (attribute)| attribute in the substance hierarchy.

Currently poisoning concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Note that role groupers

will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release.

No use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product-containing concepts can be used for modeling in this subhierarchy.

Examples to be added - pending implementation of roles and products as causative agents

Examples to be added - pending implementation of roles and products as causative agents