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HierarchyConcept typeAllowedExceptionExamples and Notes (Note: Examples are existing concepts and may not reflect the terming patterns described in the template.)
SubstanceBaseyesn/a

Example:

  • 295184007 |Morphine overdose (disorder)|
SubstanceModificationyesyes

Concepts representing substance modifications are exceptions and may be included if the overdose profile is significantly different from the substance base.

Exception examples:

  • Liposome or lipid complex substances (e.g. 412088006 |Amphotericin B liposome (substance)|, 426490000 |Vincristine liposome (substance)|)
  • Pegylated substance (e.g. 385544005 |Pegfilgrastim (substance)|, 770965008 |Pegvaliase (substance)|)
  • Salt forms (e.g. 273948005 |Chloral hydrate (substance)|, 396063006 |Fluphenazine decanoate (substance)|)

Example:

  • 296136008 |Chloral hydrate overdose (disorder)|
  • 296213007 |Fluphenazine decanoate overdose (disorder)|
Multiple substanceyesOverdose concepts representing multiple substances should be modeled using a GCIs, with Causative agent that is a descendant of 105590001 |Substance (substance)|; preferentially modeling with the base rather than a modification unless the overdose profile is significantly different from the substance base.

Example:

  • 1149374003 |Dextropropoxyphene and/or paracetamol overdose (disorder)|
  • 1149371006 |Sulfamethoxazole and/or trimethoprim overdose (disorder)|
SubstanceDisposition grouperyesn/a

Overdose concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

  • 297053006 |Overdose of angiotensin-converting-enzyme inhibitors (disorder)|
  • 296515004 |Opiate antagonist overdose (disorder)|
SubstanceRole grouperyesn/a

Overdose concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release.

Example:

  • 297006008 |Diuretic overdose (disorder)|
  • 295217003 |Non-steroidal anti-inflammatory overdose (disorder)|
SubstanceStructure grouperyesn/a

Overdose concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

  • 295188005 |Pethidine analog overdose (disorder)|
  • 1155996000 |Phenothiazine and/or phenothiazine derivative overdose (disorder)|

Expected classification:

  • Classification results are expected to be consistent with the Substance hierarchy and with other existing concepts in the subhierarchy.
ProductStructure groupernon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductDisposition groupernon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductRole groupernon/a

Overdose concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release.

ProductMedicinal product-containingnon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductMedicinal product-onlynon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductMedicinal product form-containingnon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
Product

Medicinal product form-only

non/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductClinical drugnon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.

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