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Termdescription typeLanguage/acceptabilityLangauge/acceptabilityCase significance

[Accidental/Intentional] [course] [substance or product] overdose  overdose (disorder)

FSNus:Pgb:Pci

[Accidental/Intentional] [course] [substance or product] overdose overdose

SYNus:Pgb:Pci

Concept model:

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The following editorial guidelines apply to concepts in the International Release; editorial guidelines for concepts in national extensions may vary.

HierarchyConcept
Causative agent
typeAllowedExceptionExamples and Notes (Note: Examples are existing concepts and may not reflect the terming patterns described in the template.)
Substance
base
Baseyes
Overdose concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.Substance modificationno, unless documented as exceptionOverdose concepts representing a substance modification should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.
n/a

Example:

  • 295184007 |Morphine overdose (disorder)|

Expected classification:

  • Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy.
SubstanceModificationyesyes

Concepts representing substance modifications are exceptions and may be included if the overdose profile is significantly different from the substance base.

Exception examples:

  • Liposome or lipid complex substances (e.g. 412088006 |Amphotericin B liposome (substance)|, 426490000 |Vincristine liposome (substance)|)
  • Pegylated substance (e.g. 385544005 |Pegfilgrastim (substance)|, 770965008 |Pegvaliase (substance)|)
  • Salt forms (e.g. 273948005 |Chloral hydrate (substance)|, 396063006 |Fluphenazine decanoate (substance)|)

Example:

  • 296136008 |Chloral hydrate overdose (disorder)|
  • 296213007 |Fluphenazine decanoate overdose (disorder)|
Expected classification:
  • Classification results are expected to reflect that the concept modeled with the modified substance is a descendant of the concept modeled with the base substance (if such a concept exists.
Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the

Multiple substanceyes

Overdose concepts representing multiple substances should be modeled using a GCIs, with Causative agent that is a descendant of 105590001 |Substance (substance)|; preferentially modeling with the base rather than a modification unless the overdose profile is significantly different from the substance base.

Example:

  • 1149374003 |Dextropropoxyphene and/or paracetamol overdose (disorder)|
  • 1149371006 |Sulfamethoxazole and/or trimethoprim overdose (disorder)|
SubstanceDisposition grouperyesn/a

Overdose concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

  • 297053006 |Overdose of angiotensin-converting-enzyme inhibitors (disorder)|
  • 296515004 |Opiate antagonist overdose (disorder)|

Expected classification results:

Substance
hierarchy.
Role grouperyesn/a

Overdose concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Note that role Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the

Role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release.

Example:

  • 297006008 |Diuretic overdose (disorder)|
  • 295217003 |Non-steroidal anti-inflammatory overdose (disorder)|

Expected classification results (to be revised when concepts are remodeled using Medicinal product ):

Substance
hierarchy.
Structure grouperyesn/a

Overdose concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

  • 295188005 |Pethidine analog overdose (disorder)|
  • 1155996000 |Phenothiazine and/or phenothiazine derivative overdose (disorder)|

Expected classification:

  • Classification results are expected to be consistent with the Substance hierarchy and with other existing concepts in the
subhierarchy.Descendant of 373873005 |Pharmaceutical / biologic
  • subhierarchy.
ProductStructure groupernon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductDisposition groupernon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductRole groupernon/a

Overdose concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release.

Product
no, unless documented as exception
Medicinal product-containingnon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductMedicinal product-onlynon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductMedicinal product form-containingnon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
Product

Medicinal product form-only

non/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
ProductClinical drugnon/aNo use case has been identified for use of this concept type for modeling in this subhierarchy.
Exceptions: None identified

The following types of groupers are out of scope; existing concepts have been inactivated or will be addressed in future release:

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