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Exceptions:
There are few exceptions in modeling the causative agent attribute for descendants of the 419199007 |Allergy to substance (finding)| in comparison to the general template guidelines:
- 788802000|Allergy to cetuximab (finding)|
- The allergy is to alpha-gal substance in a product containing cetuximab.
- 432807008 |Pollen-food allergy (finding)|
- This is a contact food allergy that occurs in patients with pollen allergy when ingesting raw fruits, vegetables and some tree nuts. Symptoms are caused by a heat-labile protein in fruits, vegetables, and nuts that cross-reacts with proteins in aeroallergens.
- 293908005 |Allergy to chloral hydrate (finding)|
- In general, concepts in the 419199007 |Allergy to substance (finding)| sub-hierarchy are modeled with the base substance and not its modification. Chloral hydrate is an exception to this rule.
Please note that for the first two: since it is hard to fully define these concepts, they have been left as primitive concepts.