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Hierarchy

Concept type

Allowed

Exception

Examples and Notes

SubstanceBaseyesnone

Example:

  • 294418003 |Allergy to phenol (finding)|

Expected classification (Agreed 21-Jan-2020):

  • Classification results are expected to be consistent with the modeling in the Substance hierarchy.
SubstanceModificationnoyes

Example:

293908005 |Allergy to chloral hydrate (finding)|

Chloral hydrate is a sedative and may not be well-represented by "Chloral derivative".

Expected classification (Agreed 21-Jan-2020):

  • Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy. Concepts modeled using a modification should have the concept modeled using the base as an inferred parent if such a concept exists.
    • 782530003 |Allergy to chloral derivative (finding)| will be modeled with Causative agent = 418037002 |Chloral derivative (substance)| and will have the following inferred descendants:
      • 293908005 |Allergy to chloral hydrate (finding)|
SubstanceDisposition grouperyesnone

Example:

  • 294275005 |Allergy to opioid receptor antagonist (finding)|

Expected classification results (Agreed 21-Jan-2020):

  • Classification results are expected to be consistent with the modeling in the Substance hierarchy for concepts modeled with an attribute value from the Substance hierarchy.
ProductDisposition groupernononeNo use case has been identified for use of this concept type for modeling in this subhierarchy. Disposition groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)
SubstanceRole groupernonone

Role groupers in the Substance hierarchy will be inactivated in a future release and should not be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)

ProductRole grouperyesnone

Example:

417930000 |Allergy to adhesive agent (finding)|

Expected classification results: NEEDS INTERNAL AGREEMENT

Classification results are expected to be consistent with the modeling in the Substance hierarchy.
  • TBD if there are any restrictions on which product roles can be used in modeling in this subhierarchy
  • SubstanceStructure grouperyesnone

    Example:

    • 782607004 |Allergy to phenothiazine derivative (finding)|

    Expected classification (Agreed 21-Jan-2020):

    • Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.
    ProductStructure groupernonone

    No use case has been identified for use of this concept type for modeling in this subhierarchy. Structure groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)


    ProductMedicinal product-containingyesnone

    Example:

    • 294522005 |Allergy to ampicillin and cloxacillin (finding)|

    Expected classification results: NEEDS INTERNAL AGREEMENT

    • 294650000 |Allergy to vaccine product containing Mumps orthorubulavirus antigen (finding)|

    Expected classification results: Needs input from Drugs WG - see DRUGS-865https://confluence.ihtsdotools.org/display/IAP/Allergy+to+X+vaccine

    ProductMedicinal product-onlynononeNo use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product-containing concepts can be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)
    ProductMedicinal product form-containingnononeNo use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product form-containing concepts can be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)
    ProductMedicinal product form-onlynononeNo use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product form-containing concepts can be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)
    ProductClinical drugnononeNo use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product form-containing concepts can be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)

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