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As part of an implementation process it is relevant to consider any optimization that could be done to meet requirements for implementation or result in a more effective and/or efficient use at runtime.  Because, even though reference sets are distributed in separate files and represented according to the reference set file format, it may be useful to transform these reference sets files into another structure that is more appropriate for the specific use case.

Prior to implementation a reference set may be transformed into one or more formats, which are optimized for the particular use of the reference set

Optimizations that could be considered include:

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