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Overview

The dose form release characteristic represents a general type of pattern of release (e.g. conventional, modified, delayed, prolonged) of the active ingredient substance(s) from the dose form. To support fully defining concepts in the 736542009 |Pharmaceutical dose form (dose form)| hierarchy, a hierarchy representing dose form release characteristics is required.

Concepts in the 736480007 |Dose form release characteristic (release characteristic)| hierarchy will be used to model concepts in the 736542009 |Pharmaceutical dose form (dose form)| hierarchy; they will not be used to model concepts in the 763158003 |Medicinal product (product)| hierarchy.

The 736480007 |Dose form release characteristic (release characteristic)| hierarchy is a descendant of 362981000 |Qualifier value (qualifier value).

Modeling (stated view)

Descendants shall be modeled as follows.

Parent concept

736480007 |Dose form release characteristic (release characteristic) or one or more descendants of 736480007 |Dose form release characteristic (release characteristic)

Semantic tag

(release characteristic)

Definition status

900000000000074008 |Necessary but not sufficient concept definition status (core metadata concept)

AttributesNone

Naming Guidelines

FSN

Use the following pattern for the FSN where X is the release characteristic, adding a hyphen when appropriate Combined release-characteristic concepts may be created to support modeling of concepts that display multiple release characteristics in a single formulation.

  • X (release characteristic)

Example:

  • Conventional release (release characteristic)
  • Delayed-release (release characteristic)
  • Prolonged-release (release characteristic)*
  • Modified-release (release characteristic)**
  • Delayed-release and prolonged-release (release characteristic)

*Prolonged was selected rather than Extended because feedback was received that it is more clear to translate for non-English speaking users; existing national drug extensions appear to use one or the other of these terms.

**Modified-release is a grouper that is not allowed to be used to model a Clinical drug concept.

Preferred Term

Use the following pattern for the PT where X is the release characteristic, adding a hyphen when appropriate:

  • X

Example:

  • Conventional release
  • Delayed-release
  • Prolonged-release
  • Modified-release
  • Delayed-release and prolonged-release

Synonyms

Synonyms are not allowed unless explicitly identified as an exception in the Editorial Guidelines.

Exceptions: none

Text DefinitionsPreferred; not required.

Exemplars

The following illustrates the stated and inferred view for 736849007 |Conventional release (release characteristic)|:


The following illustrates the stated and inferred view for 736848004 |Delayed-release (release characteristic)|:


The following illustrates the stated and inferred view for 737594003 |Delayed-release and prolonged-release (release characteristic)|:


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