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Overview

A recombinant (A new entity e.g., gene, protein, cell, or individual that results from genetic recombination) or synthetic/semi-synthetic substance (of, relating to, or produced by chemical or biochemical synthesis; especially: produced artificially) is similar in structure (but not identical to the naturally occurring substance). It should be created as a sibling of the naturally occurring substance.
A substance that is part of (e.g. dander) or is derived from (e.g. Insulin) an organism (human or non-human) is identical and should be created as a child of the naturally occurring substance.

Parent concept	Most distal appropriate descendant of 105590001 \|Substance (substance)\|
Semantic tag	(substance)
Definition status	900000000000074008 \|Necessary but not sufficient concept definition status (core metadata concept)\|
Attribute	738774007 \|Is modification of (attribute)\| as applicable 726542003 \|Has disposition (attribute)\| as appropriate

“Recombinant”, “Synthetic”, or “Semi-synthetic” should precede the name of the substance

The source organism name should precede the name of the substance

An exception to this rule is the naming of DNA, RNA, rRNA, antibody, Immunoglobulin, and antigen of organisms, which should follow the guideline specified for antibodies and antigens
For some non-human sources, there are different ways of referring to the source organism:
- The common name of the organism e.g. pig, cow, horse, mouse, sheep
  - The common name of an organism is used when referring to a part of the organism or to non-meat products
    - E.g. Pig epithelium, Cow milk
- An adjective referring to the organism, e.g. porcine, bovine, equine, murine, ovine
  - The adjective is usually used when referring to a substance extracted from the organism
    - E.g. Bovine growth hormone (substance), Porcine calcitonin (substance)
- The adjective is commonly used in referring to the organism hosting a virus, but there are exceptions. In general, proper name of organism such as virus name should be preserved as it is (including the case sensitivity):
  - Ribonucleic acid of Bovine leukemia virus (substance)
  - Immunoglobulin G antibody to Eastern equine encephalitis virus (substance)
  - Antigen of Nairobi sheep disease virus (substance)

Additional adjectives (such as labeled, Iodinated) should proceed the name of source organism

For example,

If a concept includes “recombinant” or “synthetic” as well as a source organism, “recombinant” or “synthetic” should precede the source organism name

For example,

FSN

Pattern:

For example,

- - Human antithrombin III (substance)
  - Recombinant thrombin (substance)
  - Synthetic steroid (substance)

Preferred Term

Pattern:

For example,

Exception

The naming of DNA, RNA, rRNA, antibody, Immunoglobulin, and antigen of organisms should follow the specific guideline for this type of substances.

Exemplar

Stated view of 411973001 |Bovine thrombin (substance)|

SNOMED CT Editorial Guide > Substances specifying a source or origin > image2019-5-22_17-14-33.png