A.6 Nested Expression Constraints - Valid Expressions

Expression Constraint	Valid Expression¹
	Precoordinated	Postcoordinated
<< (^ 700043003 \| Example problem list concepts reference set\| )	394659003 \| Acute coronary syndrome\|	194828000 \|Angina\| : 255234002 \|After\| = 22298006 \|Myocardial infarction\|
	194828000 \| Angina\|
	371807002 \| Atypical angina\|
^ (< 450973005 \| GP/FP health issue reference set\| )	140004 \| Chronic pharyngitis\|	-
	297009 \| Acute myringitis\|
(< 404684003 \|Clinical finding\| : 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| ) AND ^ 700043003 \|Example problem list concepts reference set\|	204351007 \| Fallot's trilogy\|	-
	457652006 \| Calcification of pulmonary valve\|
(< 404684003 \|Clinical finding\| : 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| ) AND (< 64572001 \|Disease\| : 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\| )	204351007 \| Fallot's trilogy\|	19036004 \|Rheumatic heart valve stenosis\| : { 363698007 \|Finding site\| = 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = 415582006 \|Stenosis\| }
	56786000 \| Pulmonic valve stenosis\|
(<< 17636008 \|Specimen collection\| : 424226004 \|Using device\| = << 19923001 \|Catheter\| ) . 363701004 \|Direct substance\|	78014005 \| Urine\|	-
	87612001 \| Blood\|
(<< 404684003 \|Clinical finding (finding)\| OR << 272379006 \|Event (event)\| ): 255234002 \|After\| = << 71388002 \|Procedure (procedure)\|	235948002 \| Postoperative acute pancreatitis\|	64572001 \|Disease\| : { 370135005 \|Pathological process\| = 441862004 \|Infectious process\| , 255234002 \|After\| = 387713003 \|Surgical procedure\| , 116676008 \|Associated morphology\| = 112633009 \|Surgical would\| }
	441795000 \| Infected seroma after surgical procedure\|
<< 125605004 \|Fracture of bone\| : [0..0] ((<< 410662002 \|Concept model attribute\| MINUS 363698007 \|Finding site\| ) MINUS 16676008 \|Associated morphology\| ) = *	125605004 \| Fracture of bone\|	64572001 \| Disease\| : { 363698007 \| Finding site\| = 71341001 \| Bone structure of femur\| , 116676008 \| Associated morphology\| = 20946005 \| Fracture, closed\| }
	439987009 \| Open fracture of bone\|
< 404684003 \|Clinical finding\| : 47429007 \|Associated with\| = (< 404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = << 55641003 \|Infarct\| )	71023004 \| Pericarditis secondary to acute myocardial infarction\|	3238004 \| Pericarditis (disorder)\| : 47429007 \| Associated with\| = 57054005 \| Acute myocardial infarction\|

Footnotes
Ref	Notes
1	Where necessary, these examples make some assumptions about the membership of the example reference sets.

Expression Constraint	Valid Expression¹
	Precoordinated	Postcoordinated
<< (^ 700043003 \| Example problem list concepts reference set\| )	394659003 \| Acute coronary syndrome\|	194828000 \|Angina\| : 255234002 \|After\| = 22298006 \|Myocardial infarction\|
	194828000 \| Angina\|
	371807002 \| Atypical angina\|
^ (< 450973005 \| GP/FP health issue reference set\| )	140004 \| Chronic pharyngitis\|	-
	297009 \| Acute myringitis\|
(< 404684003 \|Clinical finding\| : 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| ) AND ^ 700043003 \|Example problem list concepts reference set\|	204351007 \| Fallot's trilogy\|	-
	457652006 \| Calcification of pulmonary valve\|
(< 404684003 \|Clinical finding\| : 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| ) AND (< 64572001 \|Disease\| : 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\| )	204351007 \| Fallot's trilogy\|	19036004 \|Rheumatic heart valve stenosis\| : { 363698007 \|Finding site\| = 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = 415582006 \|Stenosis\| }
	56786000 \| Pulmonic valve stenosis\|
(<< 17636008 \|Specimen collection\| : 424226004 \|Using device\| = << 19923001 \|Catheter\| ) . 363701004 \|Direct substance\|	78014005 \| Urine\|	-
	87612001 \| Blood\|
(<< 404684003 \|Clinical finding (finding)\| OR << 272379006 \|Event (event)\| ): 255234002 \|After\| = << 71388002 \|Procedure (procedure)\|	235948002 \| Postoperative acute pancreatitis\|	64572001 \|Disease\| : { 370135005 \|Pathological process\| = 441862004 \|Infectious process\| , 255234002 \|After\| = 387713003 \|Surgical procedure\| , 116676008 \|Associated morphology\| = 112633009 \|Surgical would\| }
	441795000 \| Infected seroma after surgical procedure\|
<< 125605004 \|Fracture of bone\| : [0..0] ((<< 410662002 \|Concept model attribute\| MINUS 363698007 \|Finding site\| ) MINUS 16676008 \|Associated morphology\| ) = *	125605004 \| Fracture of bone\|	64572001 \| Disease\| : { 363698007 \| Finding site\| = 71341001 \| Bone structure of femur\| , 116676008 \| Associated morphology\| = 20946005 \| Fracture, closed\| }
	439987009 \| Open fracture of bone\|
< 404684003 \|Clinical finding\| : 47429007 \|Associated with\| = (< 404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = << 55641003 \|Infarct\| )	71023004 \| Pericarditis secondary to acute myocardial infarction\|	3238004 \| Pericarditis (disorder)\| : 47429007 \| Associated with\| = 57054005 \| Acute myocardial infarction\|

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A.6 Nested Expression Constraints - Valid Expressions