A.1 Simple Expression Constraints

Expression Constraint	Valid Expression¹
	Precoordinated	Postcoordinated
404684003 \|Clinical finding\|	404684003 \|Clinical finding\|	-
< 404684003 \|Clinical finding\|	64572001 \|Disease\|	404684003 \|Clinical finding\| : 363698007 \|Finding site\| = 80891009 \|Heart structure\|
	56265001 \|Heart disease\|
<< 73211009 \|Diabetes mellitus\|	73211009 \|Diabetes mellitus\|	73211009 \|Diabetes mellitus\| : 42752001 \|Due to\| = 61823004 \|Injury of pancreas\|
	46635009 \|Diabetes mellitus type 1\|
	105401000119101 \|Diabetes mellitus due to pancreatic injury\|
<! 404684003 \|Clinical finding\|	64572001 \|Disease\|	404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|
	267038008 \|Edema\|
> 40541001 \|Acute pulmonary edema\|	111273006 \|Acute respiratory disease\|	64572001 \|Disease\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\| , 363698007 \|Finding site\| = 39607008 \|Lung structure\|
	404684003 \|Clinical finding\|
	138875005 \|SNOMED CT concept\|
>> 40541001 \|Acute pulmonary edema\|	40541001 \|Acute pulmonary edema\|	64572001 \|Disease\| : 263502005 \|Clinical course\| = 424124008 \|Sudden onset AND/OR short duration\| , { 116676008 \|Associated morphology\| = 40829002 \|Acute edema\| , 363698007 \|Finding site\| = 39607008 \|Lung structure\| }
	111273006 \|Acute respiratory disease\|
	404684003 \|Clinical finding\|
	138875005 \|SNOMED CT concept\|
>! 40541001 \|Acute pulmonary edema\|	111273006 \|Acute respiratory disease\|	19829001 \|Disorder of lung\| : { 116676008 \|Associated morphology\| = 79654002 \|Edema\| , 363698007 \|Finding site\| = 39607008 \|Lung structure\| }
	19242006 \|Pulmonary edema\|
^ 700043003 \|Example problem list concepts reference set\|	394659003 \|Acute coronary syndrome\|	-
	194828000 \|Angina\|
	29857009 \|Chest pain\|
*	138875005 \|SNOMED CT concept\|	404684003 \|Clinical finding\| : 363698007 \|Finding site\| = 80891009 \|Heart structure\|
	404684003 \|Clinical finding\|	71388002 \|Procedure\| : 405813007 \|Procedure site - Direct\| = 66754008 \|Appendix structure\|
	322236009 \|Paracetamol 500mg tablet\|	373873005 \|Pharmaceutical / biologic product\| : { 127489000 \|Has active ingredient\| = 412031009 \|Paracetamol or derivative\| }

Footnotes
Ref	Notes
1	Where necessary, these examples make some assumptions about the membership of the example reference sets.

Expression Constraint	Valid Expression¹
	Precoordinated	Postcoordinated
404684003 \|Clinical finding\|	404684003 \|Clinical finding\|	-
< 404684003 \|Clinical finding\|	64572001 \|Disease\|	404684003 \|Clinical finding\| : 363698007 \|Finding site\| = 80891009 \|Heart structure\|
	56265001 \|Heart disease\|
<< 73211009 \|Diabetes mellitus\|	73211009 \|Diabetes mellitus\|	73211009 \|Diabetes mellitus\| : 42752001 \|Due to\| = 61823004 \|Injury of pancreas\|
	46635009 \|Diabetes mellitus type 1\|
	105401000119101 \|Diabetes mellitus due to pancreatic injury\|
<! 404684003 \|Clinical finding\|	64572001 \|Disease\|	404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|
	267038008 \|Edema\|
> 40541001 \|Acute pulmonary edema\|	111273006 \|Acute respiratory disease\|	64572001 \|Disease\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\| , 363698007 \|Finding site\| = 39607008 \|Lung structure\|
	404684003 \|Clinical finding\|
	138875005 \|SNOMED CT concept\|
>> 40541001 \|Acute pulmonary edema\|	40541001 \|Acute pulmonary edema\|	64572001 \|Disease\| : 263502005 \|Clinical course\| = 424124008 \|Sudden onset AND/OR short duration\| , { 116676008 \|Associated morphology\| = 40829002 \|Acute edema\| , 363698007 \|Finding site\| = 39607008 \|Lung structure\| }
	111273006 \|Acute respiratory disease\|
	404684003 \|Clinical finding\|
	138875005 \|SNOMED CT concept\|
>! 40541001 \|Acute pulmonary edema\|	111273006 \|Acute respiratory disease\|	19829001 \|Disorder of lung\| : { 116676008 \|Associated morphology\| = 79654002 \|Edema\| , 363698007 \|Finding site\| = 39607008 \|Lung structure\| }
	19242006 \|Pulmonary edema\|
^ 700043003 \|Example problem list concepts reference set\|	394659003 \|Acute coronary syndrome\|	-
	194828000 \|Angina\|
	29857009 \|Chest pain\|
*	138875005 \|SNOMED CT concept\|	404684003 \|Clinical finding\| : 363698007 \|Finding site\| = 80891009 \|Heart structure\|
	404684003 \|Clinical finding\|	71388002 \|Procedure\| : 405813007 \|Procedure site - Direct\| = 66754008 \|Appendix structure\|
	322236009 \|Paracetamol 500mg tablet\|	373873005 \|Pharmaceutical / biologic product\| : { 127489000 \|Has active ingredient\| = 412031009 \|Paracetamol or derivative\| }

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A.1 Simple Expression Constraints