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The Clinical Drug (CD precisely) (presentation) concept is defined by three attributes and a set of substance/strength attributes:

411116001 |Has manufactured dose form|

763032000 |Has unit of presentation|

1142139005 |Count of base of active ingredient|

762949000 |Has precise active ingredient|

732943007 |Has basis of strength substance|

1142135004 |Has presentation strength numerator value|

732945000 |Has presentation strength numerator unit|

1142136003 |Has presentation strength denominator value|

732947008 |Has presentation strength denominator unit|

For concepts that have two or more active ingredient substances that are modifications of the same base substance where MP precisely concepts are required, and for single ingredient product concepts where the active substance is an ingredient in these multiple modification multi-ingredient products, the following extra ingredient count attribute will be required:

1142141006 |Count of base and modification pair|

For concepts that have two or more active ingredient substances that are modifications of the same base active ingredient substance (i.e. parent ingredient substance) and where one is a further modification of the other (for example, a multi-ingredient product containing both dexamethasone phosphate and dexamethasone sodium phosphate, where the dexamethasone phosphate is a modification of dexamethasone (base) and dexamethasone sodium phosphate is a further modification of the dexamethasone phosphate) where MP precisely concepts are required, and for single ingredient product concepts where the active substance is an ingredient in these multiple modification multi-ingredient products, the following extra ingredient count attribute will be required:

1142140007 |Count of active ingredient|

As discussed above, and as described in the MRCM rules, for practical and pragmatic reasons the additional ingredient count attributes have to be applied iteratively based on requirement. 

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The Clinical Drug (CD precisely) (concentration) concept is defined by two attributes and a set of substance/strength attributes; a Clinical Drug described only by concentration strength does not have a unit of presentation:

411116001 |Has manufactured dose form|

1142139005 |Count of base of active ingredient|

762949000 |Has precise active ingredient|

732943007 |Has basis of strength substance|

1142138002 |Has concentration strength numerator value|

733725009 |Has concentration strength numerator unit|

1142137007 |Has concentration strength denominator value|

733722007 |Has concentration strength denominator unit|

For concepts that have two or more active ingredient substances that are modifications of the same base substance where MP precisely concepts are required, and for single ingredient product concepts where the active substance is an ingredient in these multiple modification multi-ingredient products, the following extra ingredient count attribute will be required:

1142141006 |Count of base and modification pair|

For concepts that have two or more active ingredient substances that are modifications of the same base active ingredient substance (i.e. parent ingredient substance) and where one is a further modification of the other (for example, a multi-ingredient product containing both dexamethasone phosphate and dexamethasone sodium phosphate, where the dexamethasone phosphate is a modification of dexamethasone (base) and dexamethasone sodium phosphate is a further modification of the dexamethasone phosphate) where MP precisely concepts are required, and for single ingredient product concepts where the active substance is an ingredient in these multiple modification multi-ingredient products, the following extra ingredient count attribute will be required:

1142140007 |Count of active ingredient|

As discussed above, and as described in the MRCM rules, for practical and pragmatic reasons the additional ingredient count attributes have to be applied iteratively based on requirement. 

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