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All Reference Sets that are released from IHTSDO or from a National Release Center will have an associated Descriptor for the Reference Set. However, Descriptors are optional for other organizations that create Reference Sets. Where you are using a Reference Set for which a Descriptor has not been created, and you need additional information about the Reference Set, the Descriptor of the closest ancestor of the concept describing the Reference Set that does have a Descriptor may be used. This situation should be rare, as an organization that releases Reference Sets should only release them without Descriptors if it is sure that its consumers do not require the information held within the Descriptors.