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In the disorder hierarchy, the word 'disorder' in singular should be used. When the concept is a general grouper of disorders of a body system, body site, or other broad general category, the word 'disorder' should be used in preference to 'disease' for the FSN. This rule in favor of 'disorder' over 'disease' applies only to broad groupers, and is not applied at 'leaf' level. Plurals such as 'disorders' or 'diseases' may only be used in synonym terms for grouper concepts.

Strings should avoid the article 'the' in the string.

Table 86: Examples of use of the words 'disorder' and 'disease' for general groupers: 

At a general level, use:Instead of:
Disorder of noseDiseases of the nose
Disorder of reproductive systemDisease of the reproductive system
Disorder of lower respiratory systemDisease of the lower respiratory system

7.5.1 Naming convention for Adverse reaction 

7.5.1.1 Adverse reaction caused by substance

  1. Use the International Nonproprietary name (INN)

    Example:

 FSN: Adverse reaction caused by abacavir (disorder)

PT:   Adverse reaction caused by abacavir
 

2. Where BAN (British Approved Name) and/or USAN (United States Adopted Name) differs from the INN, then synonyms should be added using the following pattern (Z = BAN or USAN)

    Example:

FSN: Adverse reaction caused by paracetamol (disorder)

PT:   Adverse reaction caused by paracetamol

Syn: Adverse reaction caused by acetaminophen

7.5.1.2 Adverse reaction caused by organism

  1.  Use the scientific name for the organism in FSN; common name in Preferred term and synonym to match FSN

    Example:

FSN: Adverse reaction caused by Artemisia vulgaris pollen (disorder)

PT: Adverse reaction caused by mugwort

Syn: Adverse reaction caused by Artemisia vulgaris pollen

7.5.1.3 Adverse reaction caused by multiple substances

  1. Use the International Nonproprietary name (INN, listing substances in alphabetical order

    Example:

FSN: Adverse reaction caused by sulfamethoxazole and trimethoprim (disorder)

PT: Adverse reaction caused by sulfamethoxazole and trimethoprim

2. When the BAN (British Approved Name) and/or USAN (United States Adopted Name) differs from the INN, then synonyms should be added using the following pattern, with Z = BAN or USAN
 
    Example:

FSN: Adverse reaction caused by ibuprofen and paracetamol (disorder)

PT:   Adverse reaction caused by ibuprofen and paracetamol

Syn: Adverse reaction caused by acetaminophen and ibuprofen

7.5.2 Modeling exemplar for single ingredient concepts

 The following illustrates proximal primitive modeling for single ingredient concepts fitting the pattern described in this document: 

Screen Shot 2016-08-30 at 7.25.21 PM.png 

7.5.3 Modeling exemplar for multiple ingredient concepts


The following illustrates proximal primitive modeling for multiple ingredient concepts fitting the pattern described in this document:

Screen Shot 2016-08-30 at 9.29.28 PM.png

Note: It is agreed that this modeling approach for multiple ingredient concepts is an interim solution as it is incorrectly it asserts an adverse reaction to each, rather than to one, of the agents. The use of concepts from the Product hierarchy is being considered as a final solution but further work is required to determine if this would be a viable solution.

 

Classification

When reviewing the classification for “Adverse reaction to X” concepts, it is important to confirm that the concept does not have inferred Causative agent attributes as no use case where this would be appropriate has been identified. In the event this occurs, further changes to will be required to correct the problem.

 Inferring Causative agent attributes results in incorrect content (e.g. infers a causative agent that is more general or different than what is stated in the concept modeling) and makes the concept unsuitable for use in clinical decision support implementations.