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7.11.1 General guidelines for substances

  • Substance concepts should not contain    descriptions that refer to route of administration or dose form (e.g. inhaled, topical, oral, etc.). These attributes cannot be modeled in a primitive hierarchy and are applicable to a product formulation, not a substance. Existing instances will be addressed in an upcoming release.
     
  • Descriptions, including FSNs, Preferred terms, and/or Synonyms, in the Substance hierarchy should not contain the word "total". Terms containing the word "total" (e.g. "total cholesterol") should not be added to the Substance hierarchy. Existing terms were retired as part of the January 2015 SNOMED CT release due to the inability to differentiate the definition between the "base" substance and "total" substance (e.g. "cholesterol" versus "total cholesterol") within the context of the Substance hierarchy as well as the inability to create an appropriate relationship between the "base" and "total" concepts.

7.11.2 Naming conventions for deoxyribonucleic acid and ribonucleic acid 

Examples:

  • Ribosomal ribonucleic acid of X organism

         Parent concept: Most distal appropriate descendant of 118251005 | Microbial ribosomal ribonucleic acid (substance)

FSN: Ribosomal ribonucleic acid of Candida (substance)
Preferred Term, with Initial letter case sensitive: Candida rRNA
Synonym: Ribosomal ribonucleic acid of Candida
Parent concept: Microbial ribosomal ribonucleic acid (substance)

  • Ribonucleic acid of X organism

FSN: |Ribonucleic acid of X organism (substance)|
Preferred Term (US/GB), with Initial letter case sensitive: |X organism RNA| 
Synonyms: A synonym that matches FSN
Parent concept: Most distal appropriate descendant of |118248003|Microbial ribonucleic acid (substance)

FSN: Ribonucleic acid of Norovirus genogroup I (substance)
Preferred Term, with Initial letter case sensitive: Norovirus genogroup I RNA
Parent concept: Ribonucleic acid of Norovirus (substance)
Synonym: Ribonucleic acid of Norovirus genogroup I 

  • Deoxyribonucleic acid of X organism

FSN: |Deoxyribonucleic acid of X organism (substance)|
Preferred Term (US/GB), with Initial letter case sensitive: |X organism DNA|
Synonyms: A synonym that matches FSN
Parent concept: Most distal appropriate descendant of |118249006|Microbial deoxyribonucleic acid (substance)|

FSN: Deoxyribonucleic acid of Aspergillus terreus (substance)
Preferred Term, with Initial letter case sensitive: Aspergillus terreus DNA
Synonym: Deoxyribonucleic acid of Aspergillus terreus
Parent concept: Deoxyribonucleic acid of Aspergillus (substance)

7.11.3 Naming conventions for antibodies and antigens 

  • Antigen of X organism

FSN: |Antigen of X organism (substance)|
Preferred Term (US/GB), with Initial letter case sensitive: |X organism Ag|
Synonyms: A synonym that matches FSN
Synonyms with Initial letter case sensitive: |X organism antigen|
Parent concept: Most distal appropriate descendant of |116633006|Microbial antigen (substance)|

FSN: |Surface antigen of inactivated of X organism (substance)|
Preferred Term (US/GB), with Initial letter case sensitive: |X organism surface Ag| 
Synonyms: A synonym that matches FSN
Synonyms with Initial letter case sensitive: |X organism surface antigen|
Parent concept: Most distal appropriate descendant of |116633006|Microbial antigen (substance)|

  • Antibody to X organism

FSN: |Antibody to X organism (substance)|
Preferred Term (US/GB), with Initial letter case sensitive: |X organism Ab| Synonyms: A synonym that matches FSN
Synonyms: Anti-X antibody
Synonyms with Initial letter case sensitive: |X organism antibody|
Parent concept: Most distal appropriate descendant of |116642004|Antimicrobial antibody (substance)|

  • Immunoglobulin G, M, A, E, D antibody to X organism

FSN: |Immunoglobulin G, M, A, E, D antibody to X organism (substance)|
Preferred Term (US/GB), with Initial letter case sensitive: |X organism IgG, M, A, E, D |
Synonyms: A synonym that matches FSN
Synonyms: Anti-X organism IgG, M, A, E, D
Parent concept: Most distal appropriate descendant of |399812006|Antibody class (substance)|
Parent concept: |X species antibody (substance)| if in SNOMED CT

7.11.4 Naming conventions for antivenom 

Antivenin and antivenom concepts in the Substance Hierarchy should be descendants of | Antivenin (substance) |. 

      • Use antivenom, not antivenin, for FSNs and Preferred Terms. Synonyms containing antivenin will not be created routinely, but may be created upon request. Existing concepts that are not consistent with this naming convention will be cleaned up as a batch at a later date.
      • FSNs should be based on the scientific name, if there is a one-to-one correspondence. Naming conventions for polyvalent antivenoms (effective against multiple organisms) will not comply with this naming convention, and will be evaluated on a case-by-case basis. Preferred Terms should be based on the common name.

      • Synonyms based on the scientific name should be created in most cases.

        Useful reference: Current version of "WHO Guidelines for the Production, Control and Regulation of Snake Antivenom Immunoglobulins".